Reference of 1450754-41-2 ,Some common heterocyclic compound, 1450754-41-2, molecular formula is C7H10N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenyl)picolinic acid, an intermediate with a monocarboxylic acid(0.063g, 0.145mmol)Dissolved in 3mL anhydrous tetrahydrofuran solution,Add EDC¡¤HCl (0.04 g, 0.218 mmol),HOBT (0.024 g, 0.174 mmol) was stirred well at 0 C, then DIPEA (0.094 g, .725 mmol) was added dropwise and stirred.1h,Add inPhotoaffinity group dipyridiniumAlkynyl chainConnector(0.02g, 0.145mmol),Stir at room temperature for 24 h,After the reaction is completed, the solvent is removed under reduced pressure, and an appropriate amount of ethyl acetate is added thereto, followed by washing with water and washing with saturated sodium hydrogen carbonate, and then sat.Washed with brine, combined with EtOAc (EtOAc m.The target compound was obtained, and weighed 0.03 g, yield 41.66%. Obtaining a general formula based on the VEGFR-2 inhibitor B14 photoaffinity probe
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1450754-41-2, 2-(3-But-3-ynyl-3H-diazirin-3-yl)-ethanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Xi’an Jiaotong University; Zhang Jie; Lu Wen; Wang Sicen; Pan Xiaoyan; He Langchong; Sun Ying; Wang Jin; Song Jie; (10 pag.)CN109503553; (2019); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts