In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 112-27-6, name is 2,2′-(Ethane-1,2-diylbis(oxy))diethanol, the common compound, a new synthetic route is introduced below. COA of Formula: C6H14O4
Briefly, p-toluenesulfonyl chloride (7.50 g, 40.0 mmol) was added to a solution of triethylene glycol (60.0 g, 40.0 mmol) in pyridine (6.5 mL) and dichloromethane (400 mL) and under nitrogen. After stirring for 18 hr at room temperature, the solvent was concentrated under reduced pressure. The residue was dissolved in ethyl acetate (200 mL) and washed with aq. NaCl solution (3*200 mL). The aq. extract was back extracted with ethyl acetate (2*100 mL), and the combined ethyl acetate phases were dried over MgSO4. After filtering and evaporating to dryness the product was purified on a silica column to yield a clear oil (9.30 g, 75%). 1H NMR (300 MHz, CDCl3, TMS): delta 7.82 (d, 3JHH=8.1 Hz, 2H), 7.36 (d, 3JHH=8.1 Hz, 2H), 7.19 (t, 3JHH=3.6 Hz, 2H), 3.59-3.78 (m, 10H), 2.47 (s, 3H). 13C NMR (75 MHz, CDCl3, TMS): delta 144.86, 132.93, 129.82, 127.96, 72.48, 70.77, 70.34, 69.13, 68.70, 61.74, 21.62. IR (NaCl): v=3421, 2886, 1594, 1358, 1169, 664 cm31 1.
The synthetic route of 112-27-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Holmes, Brian T.; Snow, Arthur W.; US2009/187037; (2009); A1;,
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