Month: December 2020

Related Products of 2919-23-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2919-23-5, name is Cyclobutanol. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 2-chloro-5-nitropyridine (7.12 g, 45.0 mmol) and cyclobutanol (3.40 g, 47.2 mmol) in THF (30 mL) was vigorously stirred at 0 C. while NaH (1.18 g, 46.7 mmol) was added in three portions over ~10-20 s under air (Caution: Extensive gas evolution). Reaction residue was rinsed down with additional THF (5 mL), followed by stirring under positive argon pressure in the ice bath for 1-2 more minutes. The ice bath was then removed and the brown homogeneous solution was stirred at “rt” for 1 h. The reaction was concentrated under reduced pressure at 80 C., taken up in 0.75 M EDTA (tetrasodium salt) (150 mL), and extracted with DCM (1*100 mL, 1*50 mL). The combined organic layers were dried (Na2SO4), concentrated, taken up in MeOH (2*100 mL) and concentrated under reduced pressure at 60 C. to provide the title compound as a thick dark amber oil that crystallized upon standing (7.01 g, 80%). 1H NMR (300 MHz, CDCl3) delta 9.04 (dd, J=2.84 and 0.40 Hz, 1H), 8.33 (dd, J=9.11 and 2.85 Hz, 1H), 6.77 (dd, J=9.11 and 0.50 Hz, 1H), 5.28 (m, 1H), 2.48 (m, 2H), 2.17 (m, 2H), 1.87 (m, 1H), 1.72 (m, 1H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2919-23-5, Cyclobutanol.

Reference:
Patent; Baumann, Christian Andrew; Gaul, Michael David; US2006/281769; (2006); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20017-67-8, name is 3,3-Diphenyl-1-propanol, the common compound, a new synthetic route is introduced below. Recommanded Product: 20017-67-8

EXAMPLE 29 9-(3,3-Diphenylpropoxy)-9H-indeno[1,2-b]pyrazine-2,3(1H, 4H)-dione A suspension of 9-hydroxy-9H-indeno[1,2-b]pyrazine-2,3(1H, 4H)-dione. 1H2 O (1.0 g, 4.26 mmol) in benzene (40 ml), 3,3-diphenyl-1-propanol (10 ml) and p-toluensulfonic acid (40 mg) was refluxed with water separation for 48 hours. The reaction mixture was evaporated in vacuo to dryness, the residue was suspended in ethanol (10 ml) and the precipitate was filtered off and washed with ethanol and dried to give 0.224 g (12.5%) of the title compound. M.p. 224-228 C. 1 H-NMR(DMSO-d6, delta): 2.14-2.32 (m, 2H), 3.0-3.22 (m, 2H), 4.13 (t, 1H), 5.22 (s, 1H), 7.0-7.5 (m, 14H), 12.12 (s, 1H), 12.26 (s, 1H). Analysis: Calculated for C26 H22 N2 O3.1/2H2 O: C, 74.45; H, 5.53; N, 6.68%. Found: C, 74.37; H, 5.58; N, 6.28%.

The synthetic route of 20017-67-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Faarup; Peter; Jakobsen; Palle; Jorgensen; Anker S.; Klitgaard; Henrik; US5468748; (1995); A;,
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Synthetic Route of 702-98-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 702-98-7, name is 2-Methyladamantan-2-ol. This compound has unique chemical properties. The synthetic route is as follows.

b. Synthesis of 2-methyl-2-adamantyl acrylate 2-methyl-2-adamantanol (33 g, 0.2 mol) and triethylamine (0.22 mol) were dissolved in 300 ml of THF and then acryloyl chloride (19 g, 0.21 mol) was added slowly thereto using a dropping funnel. Then, the reaction was stirred at room temperature for about 12 hours. After completion of the reaction, excess THF was removed using a rotary evaporator and then the resultant product was poured into water. Then, the resultant product was neutralized with dilute sulfuric acid and extracted using diethyl ether and was then dried over magnesium sulfate. The diethyl ether removed crude product was vacuum-distilled to yield the desired product (yield: 80%). 1H-NMR (CDCl3; ppm): 6.3 (doublet), 6.1 (1H, dd), 5.7 (1H, d), 2.3 (2H, s), 1.5-2.1 (m) FT-IR (NaCl; cm-1): 2911, 2861, 1718, 1635, 1618, 1401, 1201

According to the analysis of related databases, 702-98-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Chem Search Corp.; US6222061; (2001); B1;,
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Electric Literature of 145691-59-4, Adding some certain compound to certain chemical reactions, such as: 145691-59-4, name is (3,5-Dibromophenyl)methanol,molecular formula is C7H6Br2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 145691-59-4.

The above benzyl alcohol (0.26 g, 1.0 mmol) and methyl (4-hydroxy-2-methylphenoxy)acetate (0.30 g, 1.5 mmol) and triphenylphosphine (0.50 g, 1.85 mmol) were dissolved in a mixture of anhydrous toluene (3-mL) and tetrahydrofuran (1 mL) and the mixture was cooled to 0¡ã C. Diisopropyl azodicarboxylate (0.22 g, 1.2 mmol) was added dropwise under nitrogen. The reaction mixture was stirred for 12 h at ambient temperature and the solvents were evaporated in vacuo. Column chromatography (silica gel Fluka 60, hexanes/ethyl acetate 98:2-90:10) gave methyl [4-(3,5-dibromo)benzyloxy]-2-methylphenoxy]acetate. Yield: 0.25 g (56percent). RF (SiO2, hexanes/ethyl acetate 8:2) 0.45. 1H NMR spectrum (300 MHz, CDCl3, deltaH): 7.61 (s, 1H); 7.48 (s, 2H); 6.80 (s, 1H); 6.67 (s, 2H); 4.92 (s, 2H); 4.60 (s, 2H); 3.80 (s, 3H); 2.28 (s, 3H).

According to the analysis of related databases, 145691-59-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Novo Nordisk A/S; US2009/209588; (2009); A1;,
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Application of 770-71-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.770-71-8, name is Adamantan-1-ylmethanol, molecular formula is C11H18O, molecular weight is 166.26, as common compound, the synthetic route is as follows.

General procedure: To the solution of starting alcohol 2 (6 mmol) in dichloromethane(8 mL) was added Et3N (0.84 mL, 606 mg, 6 mmol) inatmosphere of Ar. The mixture was cooled to 0 to 5 C and theacryloyl chloride (0.49 mL, 543 mg, 6 mmol) in dichloromethane(2 mL) was added dropwise. The resulting mixture was stirred atthis temperature for 3 h and then at room temperature for 24 h.The reaction mixture was poured into water (15 mL) and extractedwith dichloromethane (4 20 mL). The combined organic layer waswashed with brine solution (3 20 mL) and was dried over anhydrousMg2SO4. The solvent was evaporated in vacuo; the residuewas purified by preparative column chromatography on silica gel.

Statistics shows that 770-71-8 is playing an increasingly important role. we look forward to future research findings about Adamantan-1-ylmethanol.

Reference:
Article; Averina, Elena B.; Vasilenko, Dmitry A.; Gracheva, Yulia A.; Grishin, Yuri K.; Radchenko, Eugene V.; Burmistrov, Vladimir V.; Butov, Gennady M.; Neganova, Margarita E.; Serkova, Tatyana P.; Redkozubova, Olga M.; Shevtsova, Elena F.; Milaeva, Elena R.; Kuznetsova, Tamara S.; Zefirov, Nikolay S.; Bioorganic and Medicinal Chemistry; vol. 24; 4; (2016); p. 712 – 720;,
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Electric Literature of 15852-73-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 15852-73-0, name is (3-Bromophenyl)methanol, molecular formula is C7H7BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a cold (0 C) solution of 3-bromophenylethanol (39) (50 g, 267 mmol) and imidazole (27 g, 401 mmol) in DMF (500 mL) was added tert-butylchlorodiphenylsilane (83 mL, 320 mmol) and the mixture was warmed up to rt then stirred at rt for 8 h. To the reaction mixture was added saturated aqueous ammonium chloride solution and EtOAc. The organic layer was separated and washed with brine then dried over MgSO4, filtered and evaporated in vacuo. The resulting residue was purified by column chromatography on silica gel (EtOAc-hexane) to give the title compound (40) (117 g, quant.) as a white solid.1H NMR (CDCl3) delta: 1.10 (9H, s), 4.72 (2H, s), 7.16-7.27 (2H, m), 7.35-7.48 (8H, m), 7.66-7.69 (4H, m). MS (FAB) m/z: 425 (M+), calcd for C23H25BrOSi: 425.

According to the analysis of related databases, 15852-73-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Imamura, Masakazu; Nakanishi, Keita; Suzuki, Takayuki; Ikegai, Kazuhiro; Shiraki, Ryota; Ogiyama, Takashi; Murakami, Takeshi; Kurosaki, Eiji; Noda, Atsushi; Kobayashi, Yoshinori; Yokota, Masayuki; Koide, Tomokazu; Kosakai, Kazuhiro; Ohkura, Yasufumi; Takeuchi, Makoto; Tomiyama, Hiroshi; Ohta, Mitsuaki; Bioorganic and Medicinal Chemistry; vol. 20; 10; (2012); p. 3263 – 3279;,
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Related Products of 454-91-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 454-91-1, name is 1-[3-(Trifluoromethyl)phenyl]ethanol. A new synthetic method of this compound is introduced below.

Example 88 1-[3-(Trifluoromethyl)phenyl]ethyl N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate 4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethylaniline (72 mg) was added to toluene/triethylamine = 10/1 (7 ml), and the mixture was heated under reflux to prepare a solution. A solution of triphosgene (110 mg) in methylene chloride was then added to the solution, and the mixture was heated under reflux for 15 min. Subsequently, 3-trifluoromethyl-alpha-methylbenzyl alcohol (70 mg) was added thereto, and the mixture was further stirred with heating under reflux for 2 hr. After the completion of the reaction, the reaction solution was allowed to cool to room temperature before distilled water was added thereto. The mixture was subjected to separatory extraction with chloroform, followed by washing with a 1 N aqueous hydrochloric acid solution and saturated brine. The washed solution was dried over sodium sulfate and was concentrated. The residue waspurified on a column using chloroform/methanol to give the title compound (90 mg, yield 68%). 1H-NMR (CDCl3, 400 MHz): 8.39 – 8.45 (1H, m), 8.13 (1H, s), 7.40 – 7.72 (6H, m), 6.99 (1H, d, J = 9.0 Hz), 6.48 – 6.55 (2H, m), 5.93 (1H, 1, J = 6.6 Hz), 4.15 (3H, s), 4.09 (3H, s), 2.24 (3H, s), 2.07 (3H, s), 1.63 (3H, d, J = 6.6 Hz) Mass spectrometry value (ESI-MS, m/z): 542 (M++1)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,454-91-1, its application will become more common.

Reference:
Patent; KIRIN BEER KABUSHIKI KAISHA; EP1243582; (2002); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 33524-31-1, name is (2,5-Dimethoxyphenyl)methanol, the common compound, a new synthetic route is introduced below. Computed Properties of C9H12O3

EXAMPLE 1 Preparation of 2,5-dimethoxybenzyl bromide: 2,5-Dimethoxybenzyl bromide was prepared by a modified method described by A. L. Shulgin and E. M. Gal in J. Chem. Soc. (London), 1316 (1953). A solution of 4.35 ml (46.3 mmol) PBr3 in 60 ml CCl4 was added dropwise over a period of 1 hour while cooling with ice to a solution of 20 ml (138.9 mmol) 2,5-dimethoxybenzyl alcohol in 200 ml dry CCl4 and the resulting mixture stirred for 15 h at 20 C. in the absence of moisture. After decantation of the CCl4 phase and washing of the inorganic phase (phosphorous acid) with CCl4, the combined organic phases were chromatographed on neutral aluminium oxide (Alumina Woelm N-Super I) and concentrated. The crude product was purified by sublimation in a high vacuum (T=80-100 C.; 0.1 mbar); white needles (melting point 74.5 C., as measured with a Perkin Elmer DSC 7) (lit. 75-76 C.). Yield 20.2 g=45% of the theoretical.

The synthetic route of 33524-31-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bayer Aktiengesellschaft; US4859731; (1989); A;,
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Electric Literature of 2612-28-4 ,Some common heterocyclic compound, 2612-28-4, molecular formula is C6H14O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE B A mixture of 2.3 g of trans-4-(4-cyano-3-fluorophenyl)-cyclohexanecarbaldehyde, 1.2 g of 2-propylpropane-1,3-diol, 0.01 g of p-toluenesulfonic acid and 15 ml of toluene is boiled for 3 hours under a water separator and is cooled. Working up in the customary manner gives 2-[trans-4-(4-cyano-3-fluorophenyl)-cyclohexyl]-5-propyl-1,3-dioxane.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2612-28-4, 2-Propylpropane-1,3-diol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Merck Patent Gesellschaft Mit Beschrankter Haftung; US4784471; (1988); A;,
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Related Products of 111-45-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 111-45-5, name is 2-(Allyloxy)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of sodium hydroxide (4.6 g, 115 mmol) in water (25 mL) was added a solution of ethyleneglycol monoallyl ether (10.0 g, 98 mmol) in THF (50 mL) at 0 C (ice/water bath). A solution of p-toluene sulfonyl chloride (17.9 g, 93 mmol) in THF (40 mL) was added dropwise to the alkaline solution at 0 oC. After completion of addition, the reaction mixture was stirred for 1 h at room temperature and poured into ice/water. The organic materials were extracted with hexane and hexane layer was washed with brine, dried with MgSO4 , and evaporated to leave a residue which was distilled under vacuum to give 22.4 g of 2-(p-tolylsulfonyloxy)ethyl propenyl ether (1b) as a colorless oil in 93% yield (22.4 g).

According to the analysis of related databases, 111-45-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Kultyshev, Roman G.; Kawanishi, Yuji; Nishioka, Masateru; Miyazawa, Akira; Synthetic Communications; vol. 44; 4; (2014); p. 556 – 563;,
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