Month: December 2020

Related Products of 722-92-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, molecular formula is C9H7F6NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (10.0 g, 38.6 mmol) in DMF (50 mL) was dropwise added a solution of sodium nitrite (2.8 g, 40.5 mmol) in water (15.5 mL) and a 6M solution of hydrochloric acid (19.3 mL, 115.7 mmol), while maintaining the reaction temperature at 0?5 C. The reaction mixture was stirred for 30 min, and then potassium iodide (6.4 g, 38.6 mmol) was added portionwise at 0?5 C. The resulting reaction mixture was stirred overnight at rt. The reaction mixture was extracted with EtOAc, and the combined organic layers were washed with saturated sodium thiosulphate and dried over Na2SO4. The solvent was evaporated in vacuo to obtain the crude, which was purified by flash chromatography on silica gel (?5% EtOAc/Hex) to obtain the title compound.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 722-92-9, 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol.

Reference:
Patent; The Scripps Research Institute; Kamenecka, Theodore Mark; Griffin, Patrick R.; Shin, Youseung; He, Yuanjun; Blayo, Anne-Laure; Lyda, Brent R.; Koenig, Marcel; Kumar, Naresh; Burris, Thomas; (119 pag.)US9586928; (2017); B2;,
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Application of 2215-78-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2215-78-3, name is (4-Phenoxyphenyl)methanol, molecular formula is C13H12O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2-benzylamino nicotinic acid (0.228 g) in 1,2-dichloroethane, 4-phenoxybenzyl alcohol (0.200 g), 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (0. 230 g) and 4-dimethylaminopyridine (0.146 g) was added, the mixture was heated and stirred for 2 h at 80 C. After cooling to room temperature, added water and extracted with methylene chloride and extracted with further methylene chloride and the aqueous layer. The combined organic layers were dried over anhydrous sodium sulfate. And concentrated under reduced pressure, and the obtained residue is purified by silica gel column chromatography, compounds of the present invention described in Table 1 (No. 1), to give 0.246 g, an oil.

According to the analysis of related databases, 2215-78-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AGRO-KANESHOCOMPANY LIMITED; AIZAWA, RYO; HONMA, ATSUKO; OKADA, ITARU; HATAMOTO, MASAHIRO; FUKUCHI, TOSHIKI; (12 pag.)JP2016/11277; (2016); A;,
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Adding a certain compound to certain chemical reactions, such as: 2566-44-1, 2-Cyclopropylethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C5H10O, blongs to alcohols-buliding-blocks compound. Formula: C5H10O

A mixture of 2-cyclopropyl-ethanol (4.1 g) and DME (15 mL) under argon was treated with NaH (60% in mineral oil, 0.45 g). After 4 hours 5-bromo-2-fluoro-pyridine (3.0 g) was added at 000. After 4 hours at room temperature, the mixture was distributed between water and EA. The organic phase was washed twice (water), dried (Na2SO4) and concentrated. The residue was purified by chromatography (Si02 EA/heptane 1:4) to provide the subtitle compound. MS ESI: mlz = 242 [M+H].

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2566-44-1, 2-Cyclopropylethanol, and friends who are interested can also refer to it.

Reference:
Patent; SANOFI; SCHWINK, Lothar; BUNING, Christian; GLOMBIK, Heiner; GOSSEL, Matthias; KADEREIT, Dieter; HALLAND, Nis; LOHMANN, Matthias; POeVERLEIN, Christoph; RITTER, Kurt; WO2015/150565; (2015); A1;,
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Adding a certain compound to certain chemical reactions, such as: 671802-00-9, tert-Butyl 3-(2-hydroxyethoxy)propanoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C9H18O4, blongs to alcohols-buliding-blocks compound. COA of Formula: C9H18O4

To a solution of Compound (g-2) (0.15 g, 0.79 mmol) and triethylamine (0.16 g, 1.6 mmol) in THF (10 mL) was added methanesulfonyl chloride (0.13 g, 1.2 mmol) at 0 C., and then the reaction mixture was stirred at room temperature for 16 hours. The solvent was removed under reduced pressure, and the residue was dissolved in ethyl acetate (30 mL). The solution was washed with saturated aqueous sodium hydrogencarbonate, dried with sodium sulfate, and concentrated in vacuo to give Compound (g-3) (0.21 g, 100% yield). (1089) 1H-NMR (CDCl3, 400 MHz) delta: 3.68-3.64 (m, 4H), 3.03-2.99 (m, 2H), 2.98 (s, 3H), 2.44-2.41 (m, 2H), 1.38 (s, 9H).

The synthetic route of 671802-00-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SUMITOMO DAINIPPON PHARMA CO., LTD.; WATANABE, Hitoshi; ISOBE, Yoshiaki; KIMURA, Hidenori; FUJIWARA, Yuji; US2019/16711; (2019); A1;,
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Application of 83647-43-2, Adding some certain compound to certain chemical reactions, such as: 83647-43-2, name is (3-Bromo-2-methylphenyl)methanol,molecular formula is C8H9BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 83647-43-2.

Intermediate 22-1Preparation of 3-(3-bromo-2-methylbenzylidene)indolin-2-one Step 1 A mixture of (3-bromo-2-methylphenyl)methanol (prepared according to the procedures reported in US Pat. Appl. 2006/0173183, 500 mg, 2.49 mmol) in THF (20 mL) was stirred at rt and treated with 1,1,1-tris(acetyloxy)-1,1-dihydro-1,2-benziodoxol-3-(1H)-one (Dess-Martin periodinane, 1.58 g, 3.73 mmol). After 2 h, the mixture was diluted with ether (ca. 100 mL) and washed with 5% aqueous sodium bisulfite, NaHCO3 (aq) and brine, dried and concentrated. The residue was purified by column chromatography (eluting with a gradient from hexane to 55:45 hexane-EtOAc) to provide 3-bromo-2-methylbenzaldehyde as a colorless oil (343 mg, 70%). 1H NMR (400 MHz, chloroform-d) delta 10.26 (1H, s), 7.78 (2H, ddd, J=9.7, 8.0, 1.2 Hz), 7.20-7.27 (1H, m), 2.75 (3H, s).

According to the analysis of related databases, 83647-43-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Bristol-Myers Squibb Company; US2010/160303; (2010); A1;,
Alcohol – Wikipedia,
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Reference of 7287-81-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7287-81-2, name is 1-(m-Tolyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A mixture of alcohol 1 (0.50 mmol), immobilized lipase (200 mg, 0.5%(w/w) enzyme/Toyonite-200M), and molecular sieves 3A (three pieces) in dry i-Pr2O (5.0mL) in a test tube with a rubber septum was stirred at 30 C for 30 min. The reaction wasstarted by addition of vinyl acetate (93 muL, 1.0 mmol) via a syringe. The progress of thereaction was monitored by TLC. The reaction was stopped by filtration at an appropriateconversion, and the filtrate was concentrated under reduced pressure. Alcohol 1 and ester 2were separated by silica gel column chromatography.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 7287-81-2, 1-(m-Tolyl)ethanol.

Reference:
Article; Ema, Tadashi; Inoue, Hiroki; Chemistry Letters; vol. 44; 10; (2015); p. 1374 – 1376;,
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Reference of 10029-04-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.10029-04-6, name is Ethyl 2-(hydroxymethyl)acrylate, molecular formula is C6H10O3, molecular weight is 130.14, as common compound, the synthetic route is as follows.

Lithium hydroxide monohydrate (145 mg, 3.46 mmol, 5.0 eq.) was added to a solution of ethyl 2-(hydroxymethyl)acrylate (90 mg, 0.69 mmol, 1.0 eq.) in tetrahydrofuran/methanol/water (3 mL, 1/1/1, v/v/v). The reaction was stirred at room temperature for 14 hours, and concentrated. The residue was dissolved in water (10 mL), adjusted with 2 N HCl to pH=5, and then extracted with ethyl acetate (20 mL*3). The combined organic phases were dried over anhydrous sodium sulfate, and concentrated to give the title compound (70 mg, yield: 100%).

Statistics shows that 10029-04-6 is playing an increasingly important role. we look forward to future research findings about Ethyl 2-(hydroxymethyl)acrylate.

Reference:
Patent; Zhejiang DTRM Biopharma Co. Ltd.; He, Wei; (167 pag.)US2016/200730; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 2050-25-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2050-25-1, name is 2-(2-(Benzyloxy)ethoxy)ethanol, molecular formula is C11H16O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Methanesulfonyl chloride (1.5 equiv.) was added drop-wise to astirred solution of alcohol (1 equiv.) and Et3N (1.5 equiv.) in anhydrousDCM (30 mL) at 0 C under nitrogen. The reaction wasallowed to warm to room temperature, and stirred for 2 h. Thereaction mixture was poured into methanol (10 mL), and concentratedin vacuo. The reaction mixture was then diluted with diethylether (20 mL), washed with water (3 20 mL) and brine(3 20 mL). The combined organic extracts were then dried overanhydrous MgSO4, filtered, and concentrated in vacuo. The residuewas dissolved in DMF (25 mL), sodium azide (3 equiv.) was added, and the mixture was stirred at 60 C for 16 h. The reaction mixturewas concentrated in vacuo, and The reaction mixture was thendiluted with diethyl ether (50 mL), washed with water (3 20 mL)and brine (3 30 mL), dried over anhydrous MgSO4, filtered, andconcentrated in vacuo, to give a residue which was purified by flashchromatography.

According to the analysis of related databases, 2050-25-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Suthagar, Kajitha; Watson, Andrew J.A.; Wilkinson, Brendan L.; Fairbanks, Antony J.; European Journal of Medicinal Chemistry; vol. 102; (2015); p. 153 – 166;,
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Reference of 504-63-2, Adding some certain compound to certain chemical reactions, such as: 504-63-2, name is 1,3-Propanediol,molecular formula is C3H8O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 504-63-2.

General procedure: To a stirred solution of 2-naphthol (0.2 mmol) in TEAA(2 ml), was added acetic anhydride (0.22 mmol). The solutionwas stirred for 3 hours at room temperature. After consumptionof starting material (TLC monitoring, ethyl acetate/hexane, 2:8), the product formed was diluted with 1 mlH2O and extracted with 3 x 2 ml ether. The combined organiclayer was separated, dried (Na2SO4), and evaporatedunder reduced pressure to afford the desired product. 1H and13C NMR spectra were in full accordance with the structureproposed. The water in the aqueous layer was distilled under reduced pressure leaving behind the TEAA which was furtherrecycled.

According to the analysis of related databases, 504-63-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Lafuente, Leticia; Diaz, Gisela; Bravo, Rodolfo; Ponzinibbio, Agustin; Letters in Organic Chemistry; vol. 13; 3; (2016); p. 195 – 200;,
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Electric Literature of 18729-48-1, Adding some certain compound to certain chemical reactions, such as: 18729-48-1, name is 3-Methylcyclopentanol,molecular formula is C6H12O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18729-48-1.

A solution of 3-methylcyclopentanol (0.3g, 3.0mmol), triethylamine (2eq) and methanesulfonyl chloride (1.5eq) in dichloromethane (lOmL) was stirred at rt for 18h. The resultant mixture was then diluted with dichloromethane and washed with H20 and then brine. The organic phase was collected, dried (MgS04) and concentrated in vacuo to give 3- methylcyclopentyl methanesulfonate

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 18729-48-1, 3-Methylcyclopentanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CELLZOME LIMITED; HARRISON, Richard, John; OXENFORD, Sally; HOBSON, Andrew; RAMSDEN, Nigel; MILLER, Warren; WO2011/134831; (2011); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts