Month: December 2020

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 616-29-5, name is 1,3-Diaminopropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C3H10N2O

A solution of 2-carboxybenzaldehyde (4.643 g, 30.00 mmol) and NaOH (1.200 g, 30.00 mmol) in 100 ml methanol was added to 1,3-diamino-propan-2-ol (1.424 g, 15.00 mmol) in 20 ml methanol. The yellowish mixture obtained was heated to 60 C while stirring for ?4 h. Then the reaction product was cooled in an ice-bath. Excess NaBH4 (1.500 g, 39.50 mmol) was added in portions to the cold solution while stirring. The yellow color was slightly discharged. After 30 min 2 ml conc. HCl was added drop wise to destroy the excess NaBH4. Acidification of the solution to pH ? 5 by further addition of conc. HCl resulted in the precipitation of white crystalline solid. The white solid was filtered out from mother liquor and washed with water and methanol, and dried at ?80 C. Yield: 4.95 g (87%). The compound was crystallized from methanol-water solution (1:1; v/v). The product was confirmed by the elemental analysis as H3cdp¡¤H2O. Anal. Calc. for C19H22N2O5.H2O: C, 60.63%; H, 6.43%; N, 7.44%. Found: C, 60.25%; H, 6.28%; N, 7.33%. 1H NMR for sodium salt of the compound (400 MHz, D2O, 25 C, delta): 7.46-7.32 (m, 8H), 3.92-3.80 (m, 1H), 2.63 (q, 4H), 2.55 (q, 4H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 616-29-5, 1,3-Diaminopropan-2-ol.

Reference:
Article; Patra, Ayan; Haldar, Shobhraj; Vijay Kumar, Gonela; Carrella, Luca; Ghosh, Aloke Kumar; Bera, Manindranath; Inorganica Chimica Acta; vol. 436; (2015); p. 195 – 204;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13674-16-3, name is Methyl 2-hydroxy-3-phenylpropanoate. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C10H12O3

EXAMPLE 115 (S)-2-[2,6-Dibromo-4-(6-cyano-benzo[b]naphtho[2,3-d]thiophen-11-yl)-phenoxy]-3-phenyl-propionic acid Prepared from 11-(3, 5-dibromo-4-hydroxy-phenyl)-benzo[b]naphtho[2,3-d ]thiophene-6-carbonitrile (Example 58) and (R)-2-hydroxy-3-phenylpropionic acid, methyl ester (Example 97). White solid: mp 176-178 C.: NMR (CDCl3); delta8.36 (ddd, J =8,1,1 Hz, 1 H), 7.85 (d, J=8 Hz, 1 H), 7.77 (ddd, J=8, 8, 2 Hz, 1 H), 7.58 (d, J=2 Hz, 1 H), 7.61-7.54 (m, 2 H), 7.56 (d, J=2 Hz, 1 H), 7.47 (ddd, J=8, 8, 1 Hz, 1 H), 7.41 (ddd, J=8, 1, 1, 2 H), 7.36-7.26 (m, 3 H), 7.20 (ddd, J=8, 8, 1, 1 H), 6.75 (ddd, J =8, 1, 1 Hz, 1 H), 5.46 (t, J=7 Hz, 1 H), 3.59 (d, J=7 Hz, 2 H); MS (-FAB): [M-H]-, 2 bromine isotope pattern, 654 (2%), 656 (4%) 658 (2%); Anal. Calc. for C32H19Br2NO3S: C, 58.47, H, 2.91, N, 2.13 Found: C, 58.23, H, 2.69, N, 2.03.

With the rapid development of chemical substances, we look forward to future research findings about 13674-16-3.

Reference:
Patent; American Home Products Corporation; US6110962; (2000); A;,
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Adding a certain compound to certain chemical reactions, such as: 18776-12-0, 3-Chloro-1-phenylpropan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C9H11ClO, blongs to alcohols-buliding-blocks compound. Computed Properties of C9H11ClO

A mixture of 3-chloro-1 -phenylpropan-1 -ol (p281 , 7.50 g, 43.95 mmol) and 48% aqueous hydrobromic acid (98 mL) was stirred at RT for 3 hrs, then cautiously poured into a mixture of potassium carbonate (27 g) and 180 g of ice. Potassium carbonate was cautiously added up to neutral pH. The resulting mixture was extracted twice with ether, the organic phase was dried and the solvent removed under vacuum. The crude material was purified by FC on silica gel (eluting with Cy) affording (1-bromo-3-chloropropyl)benzene (p282, 7.49 g, y= 73%) as colourless oil. NMR: 1 H NMR (CDC ) delta: 7.32-7.50 (m, 5H), 5.24 (m, 1 H), 3.75 (m, 1 H), 3.61 (m, 1 H), 2.67- 2.80 (m, 1 H), 2.45-2.58 (m, 1 H)

The synthetic route of 18776-12-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; INDIVIOR UK LIMITED; CREMONESI, Susanna; MICHELI, Fabrizio; SEMERARO, Teresa; TARSI, Luca; (364 pag.)WO2016/67043; (2016); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 68327-04-8, name is (1S,2S)-2-Aminocyclopentanol hydrochloride, molecular formula is C5H12ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: (1S,2S)-2-Aminocyclopentanol hydrochloride

A solution of 75 mg intermediate 6-[6-(d ifluoromethyl)pyrid in-3-yl]-3-oxo-2-(pyrid in-3-yl)-2,3-dihydropyridazine-4-carboxylic acid, 60 mg (1 S,2S)-2-aminocyclopentanol hydrochloride (1:1),166 mg HATU, 0.15 mL ethyldiisopropylamine and 1 mg 4-dimethylaminopyridine in 2 mL ofDMF was stirred at rt for 14 hours. Then the reaction mixture was filtered and subjected toRP-HPLC (instrument: Labomatic HD-3000 HPLC gradient pump, Labomatic Labocol Vario2000 fraction collector; column: Chromatorex 0-18 125 mm x 30 mm, eluent A: 0.lvol% formic acid in water, eluent B: acetonitrile; gradient: A 85% I B 15% – A 45% I B 55%; flow: 150 mLlmin; UV-detection: 254 nm) to yield 54 mg 6-[6-(difluoromethyl)pyridin-3-yl]-N-[(1S,2S)-2- hydroxycyclopentyl]-3-oxo-2-(pyridin-3-yl)-2,3-d ihyd ropyridazine-4-carboxamide.1H NMR (400 MHz, DMSO-d6) 6 [ppm] = 1.39- 1.56 (m, 2 H), 1.58- 1.67 (m, 1 H), 1.67- 1.76(m, 1 H), 1.77- 1.87 (m, 1 H), 2.03-2.15 (m, 1 H), 3.94 (quin, 1 H), 3.98-4.07 (m, 1 H), 4.95(d, 1 H), 7.06 (t, 1 H), 7.62 – 7.67 (m, 1 H), 7.84 (d, 1 H), 8.19 (ddd, 1 H), 8.58 (dd, 1 H), 8.70(dd, 1 H), 8.76 (s, 1 H), 8.94 (d, 1 H), 9.24 – 9.29 (m, 2 H).

With the rapid development of chemical substances, we look forward to future research findings about 68327-04-8.

Reference:
Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; DEUTSCHES KREBSFORSCHUNGSZENTRUM; GUTCHER, Ilona; ROeHN, Ulrike; SCHMEES, Norbert; ZORN, Ludwig; ROeSE, Lars; BADER, Benjamin; KOBER, Christina; CARRETERO, Rafael; STOeCKIGT, Detlef; IRLBACHER, Horst; PLATTEN, Michael; (397 pag.)WO2018/146010; (2018); A1;,
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Electric Literature of 1454-85-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1454-85-9, name is Heptadecan-1-ol. A new synthetic method of this compound is introduced below.

General procedure: Alcohol (1.0 eq.) and sodium hydride (60percent in mineral oil, 2.8 eq.) were introduced in dimethoxyethane (10 mL). The solution was refluxed up to the end of H2 emission. Then, a solution of (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 4-methylbenzenesulfonate (1.4 eq.) in ethane-1,2-diol was added and the mixture was refluxed for 48 h. After cooling to room temperature, the solution was poured into water. The organic layer was extracted with diethyl ether and dried over Na2SO4. The solvents were removed under vacuum and the desired product was obtained after a purification by flash chromatography in chloroform. The advancement of the purification was followed by TLC in chloroform/acetone (90:10).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1454-85-9, its application will become more common.

Reference:
Article; Pinault, Michelle; Guimaraes, Cyrille; Couthon, Helene; Thibonnet, Jerome; Fontaine, Delphine; Chantome, Aurelie; Chevalier, Stephan; Besson, Pierre; Jaffres, Paul-Alain; Vandier, Christophe; Marine Drugs; vol. 16; 4; (2018);,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.63012-03-3, name is (3-Chlorophenyl)(phenyl)methanol, molecular formula is C13H11ClO, molecular weight is 218.68, as common compound, the synthetic route is as follows.category: alcohols-buliding-blocks

General procedure: To a solution of thiol 1 (0.5 mmol) in anhyd CH2Cl2 (2 mL) was added diaryl carbinol 2 (0.6 mmol) and BF3*OEt2 (5 mol% solution in CH2Cl2; 1 mL). The reaction mixture was stirred vigorously for <1 min. After completion of the reaction as checked by TLC, the solvent was removed under reduced pressure, and the residue was subjected to silica gel column chromatography by using 5-10% EtOAc in hexanes to afford the desired symmetrical and unsymmetrical diarylmethyl thioether in good to quantitative yield. At the same time, in my other blogs, there are other synthetic methods of this type of compound,63012-03-3, (3-Chlorophenyl)(phenyl)methanol, and friends who are interested can also refer to it. Reference:
Article; Singh, Pallavi; Peddinti, Rama Krishna; Synthesis; vol. 49; 16; (2017); p. 3633 – 3642;,
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Reference of 171623-29-3, Adding some certain compound to certain chemical reactions, such as: 171623-29-3, name is (4-Cyclopentylphenyl)methanol,molecular formula is C12H16O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 171623-29-3.

General procedure: Under nitrogen atmosphere, to asuspension of 14-21 (1.0 eq.) in dry CH2Cl2 (2.0 mL), DIPEA (1.2 eq.) was added dropwise.Subsequently, the crude mixture containing the corresponding alkyl-2-oxopyridine-1-carboxylate (1.2eq.) in dry CH2Cl2 (4.0 mL) was added. The reaction mixture was stirred at room temperature for 16 h,diluted with CH2Cl2 (10 mL), washed with sat. NH4Cl solution (2 x 20mL), sat. NaHCO3 solution (2 x20 mL), and the organic layer dried over Na2SO4 and concentrated to dryness. Purification wasperformed either by typical silica gel flash chromatography or preparative HPLC affording the desired-lactam carbamates.

According to the analysis of related databases, 171623-29-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Nuzzi, Andrea; Fiasella, Annalisa; Ortega, Jose Antonio; Pagliuca, Chiara; Ponzano, Stefano; Pizzirani, Daniela; Bertozzi, Sine Mandrup; Ottonello, Giuliana; Tarozzo, Glauco; Reggiani, Angelo; Bandiera, Tiziano; Bertozzi, Fabio; Piomelli, Daniele; European Journal of Medicinal Chemistry; vol. 111; (2016); p. 138 – 159;,
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Reference of 15852-73-0 ,Some common heterocyclic compound, 15852-73-0, molecular formula is C7H7BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step 51a: 1-Bromo-3-(methoxymethyl)benzene (Compound 0601-139)[0412]To a solution of m-bromobenzyl alcohol (1.0 g, 5.3 mmol) in THF (10 mL) was added NaH (0.26 g, 10.6 mmol) at 0¡ã C., stirred for 10 minutes, followed by addition of iodomethane (1.1 g, 7.9 mmol). The resulting reaction mixture was stirred for 1 hour. To the mixture ethyl acetate (30 mL) was added, washed with water, brine, dried over Na2SO4, filtered, and concentrated under reduced pressure to give the title compound 0601-139 (1.0 g, 93percent) as an oil. 1H NMR (400 MHz, DMSO-d6) delta 3.30 (s, 3H), 4.41 (s, 2H), 7.29 (t, J=8.0 Hz, 1H), 7.40 (t, J=7.6 Hz, 1H), 7.47 (d, J=8.0 Hz, 1H), 7.64 (d, J=8.0 Hz, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 15852-73-0, (3-Bromophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Curis, Inc.; Bao, Rudi; Lai, Chengjung; Qian, Changgeng; US2013/102595; (2013); A1;,
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Synthetic Route of 144-19-4 , The common heterocyclic compound, 144-19-4, name is 2,2,4-Trimethyl-1,3-pentanediol, molecular formula is C8H18O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 4 Synthesis of 7-Isopropyl-8,8-dimethyl-8,9-dihydro-7H-6,10-dioxabenzocyclononene-5,11-dione in a More Dilute Solution, Without the Addition of a Catalyst. A solution of 114.82 g (0.10 mole) of phthalic anhydride and 16.31 g (0.11 mole) of 2,2,4-trimethyl-1,3-pentanediol (TMPD) in 250 mL of xylene was heated for 96 hr as described in Examples 1-3. Xylene was removed on a rotary evaporator at 20 torr, at a base temperature of 68 C. The residue (30.0 g) was diluted with 30 mL of methanol and the resulting slurry cooled to 1 C., filtered, and washed with methanol which had been chilled to -20 C. to give 15.9 g (58% yield) of 7-Isopropyl-8,8-dimethyl-8,9-dihydro-7H-6,10-dioxabenzocyclononene-5,11-dione, which was 99.9% pure by vapor phase chromatography (vpc).

The synthetic route of 144-19-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Eastman Chemical Company; US5990321; (1999); A;,
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Synthetic Route of 617-94-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.617-94-7, name is 2-Phenyl-2-propanol, molecular formula is C9H12O, molecular weight is 136.191, as common compound, the synthetic route is as follows.

General procedure: The alcohol (2mmol) and the anhydride (2.2mmol) were mixed in a 10mL test tube and 1mol% of salt A (0.02mmol) was added. The tube was then capped (or under N2 purge) and the reaction mixture was stirred at room temperature (except for 1-methylcyclopentanol at 60C). After a couple of hours the acid effluent was evaporated in vacuum. The residue was then allowed to cool to room temperature and the salt was precipitated by adding 2mL hexane (or toluene). After filtration, salt was recovered, and then evaporating solvent from the filtrate afforded the crude ester product. The recovered salt was charged with the substrates, and the reaction mixture was then proceeded to the next run. The products were quantified with GC analysis by comparison to NMP as an internal standard. The products from the 1st run were further purified by column chromatography, and the isolated yields were compared with the GC/MS yields. They were all in good agreement.

Statistics shows that 617-94-7 is playing an increasingly important role. we look forward to future research findings about 2-Phenyl-2-propanol.

Reference:
Article; Lu, Norman; Chang, Wei-Hsuan; Wei, Rong-Jyun; Fang, Yung-Cheng; Han, Tu-Wen; Wang, Guo-Quan; Chang, Jia-Yaw; Wen, Yuh-Sheng; Liu, Ling-Kang; Tetrahedron; vol. 72; 24; (2016); p. 3468 – 3476;,
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