Month: December 2020

Application of 3068-00-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3068-00-6, name is 1,2,4-Butanetriol. A new synthetic method of this compound is introduced below.

To neat butane- 1 ,2,4-triol (300 g, 2.83 mol) was added 4- methylbenzenesulfonic acid (10 g, 58 mmol). The reaction mixture was heated to 180C. After 2 hours, the reaction mixture was cooled to ambient temperature and tetrahydrofuran-3-ol was afforded by distillation of the mixture under reduced pressure (10 mm Hg; the product fraction was collected at 46C).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3068-00-6, its application will become more common.

Reference:
Patent; MERCK SHARP & DOHME CORP.; ALTMAN, Michael, D.; BIENSTOCK, Corey, E.; BUTCHER, John, W.; CHILDERS, Kaleen Konrad; DI FRANCESCO, Maria Emilia; DONOFRIO, Anthony; ELLIS, John Michael; FISCHER, Christian; HAIDLE, Andrew, M.; JEWELL, James, P.; KNOWLES, Sandra Lee; NORTHRUP, Alan, B.; OTTE, Ryan, D.; PETERSON, Scott, L.; SMITH, Graham Frank; WO2013/52394; (2013); A1;,
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Application of 10602-04-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10602-04-7, name is (4-Ethynylphenyl)methanol, molecular formula is C9H8O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: The corresponding alkyne (1.1e2.2 mmol) was added to a solutionof azide ester (¡À)-2 (1 mmol), Na ascorbate (0.5 mmol) andCuSO4.5H2O (0.05 mmol) in t-BuOH (1 mL)/H2O (1 mL) underargon. The reaction mixture was transferred to the microwavesystem and was irradiated for 10e160 min between 70 and 90 C,using an irradiation power of 100 W. Removal of solvents underreduced pressure afforded a solid residue, which was purified byrecrystallization or by column chromatography on silica gel

According to the analysis of related databases, 10602-04-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Ferreira Da Costa, Joana; Garcia-Mera, Xerardo; Caamano, Olga; Brea, Jose Manuel; Loza, Maria Isabel; European Journal of Medicinal Chemistry; vol. 98; (2015); p. 212 – 220;,
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Reference of 61487-25-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.61487-25-0, name is (2-Amino-3-chlorophenyl)methanol, molecular formula is C7H8ClNO, molecular weight is 157.6, as common compound, the synthetic route is as follows.

EXAMPLE 84 Preparation of 2-benzyloxymethyl-6-chloro aniline This material was prepared from 2-amino-3-chlorobenzyl alcohol and benzyl bromide by the general procedure outlined in Example 82. The product was purified by Kugelrohr distillation to yield an oil, bp 118-125 C. (0.1 mm). The product was characterized by IR and 1 H NMR spectroscopy.

The chemical industry reduces the impact on the environment during synthesis 61487-25-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; The Dow Chemical Company; US4755212; (1988); A;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 109-83-1, name is 2-(Methylamino)ethanol. This compound has unique chemical properties. The synthetic route is as follows. Formula: C3H9NO

A soln. of 4-methoxy-2,3,6-trimethylbenzenesulfonyl chloride (2.29 g, 9.19 mmol) in THF (30 ml) was added dropwise to a soln. of 2-methylaminoethanol (0.89 g, 0.95 ml, 11.8 mmol) and Et3N (5 ml) in THF (15 ml) at 0 C. The mixture was subsequently stirred at RT for 5 h and then concentrated i. vac., the residue was taken up in NaHCO3 soln. and the mixture was extracted with EtOAc (3¡Á30 ml). The combined organic phases were dried with Na2SO4 and concentrated i. vac.Yield: 2.38 g (90%)

With the rapid development of chemical substances, we look forward to future research findings about 109-83-1.

Reference:
Patent; Gruenenthal GmbH; US2008/306084; (2008); A1;,
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Reference of 112-27-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 112-27-6, name is 2,2′-(Ethane-1,2-diylbis(oxy))diethanol. This compound has unique chemical properties. The synthetic route is as follows.

To a mixture of 2-[2-(2-hydroxyethoxy)ethoxy]ethanol (5.00 g, 33.29 mmol, 1.00 eq) and 4-methylbenzenesulfonyl chloride (1.59 g, 8.32 mmol, 0.25 eq) in dichloromethane (50 mL) was added triethylamine (1.68 g, 16.65 mmol, 2.3 mL, 0.5 eq) in one portion at 25 C under nitrogen. The mixture was stirred at 25 C for 12 hours. The mixture was washed with brine (30 mL x 2), dried with anhydrous sodium sulfate, filtered and concentrated in vacuum. The residue was purified by silica gel chromatography (Petroleum ether/Ethyl acetate = 1/1 to 0:1) to afford 2-[2-(2-hydroxyethoxy)ethoxy]ethyl 4-methylbenzenesulfonate (1.72 g, 5.65 mmol, 17% yield) as a colorless oil. LC/MS (ESI) m/z 327.0 [M+23] +; ^-NMR (400MHz, CDCb) d 7.81 (d, / = 8.3 Hz, 2H), 7.35 (d, / = 8.0 Hz, 2H), 4.22 – 4.15 (m, 2H), 3.79 – 3.67 (m, 4H), 3.67 – 3.56 (m, 6H), 2.46 (s, 3H).

According to the analysis of related databases, 112-27-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ARVINAS OPERATIONS, INC.; YALE UNIVERSITY; CREW, Andrew P.; HORNBERGER, Keith R.; WANG, Jing; DONG, Hanqing; BERLIN, Michael; CREWS, Craig M.; (1213 pag.)WO2019/195609; (2019); A2;,
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Synthetic Route of 4728-12-5, Adding some certain compound to certain chemical reactions, such as: 4728-12-5, name is (2,2-Dimethyl-1,3-dioxan-5-yl)methanol,molecular formula is C7H14O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4728-12-5.

Example 4 2,2-dimethyl-l ,3-dioxane-5-carbaldehyde4-1 4-2Under N2 atmosphere, oxalyl chloride (1.4 eq.) was dissolved in DCM then cooled to -78¡ã C. Dropwise, DMSO (2.2 eq.) was added. This solution was stirred for about 10 minutes, then triol 3-2 (1 eq.) was dissolved in more DCM for a total concentration of 0.2 M. After reacting for 5 minutes, TEA (5 eq.) was added. This mixture stirred for 10 minutes at -78¡ã C, then for another 10 minutes at room temperature. This reaction was best monitored by TLC using a 1 : 1 ratio of hexane to ethyl acetate as the developing solvent and visualizing the results with CAM stain. The reaction mixture was used without further workup.

According to the analysis of related databases, 4728-12-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS AG; WO2008/63912; (2008); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10602-04-7, name is (4-Ethynylphenyl)methanol, the common compound, a new synthetic route is introduced below. Computed Properties of C9H8O

Example 13; {4-[2,6-bis-(4-hydroxymethyl-phenylethynyl)-pyridin-4-ylsulfanyl]-2-methyl-phenoxy}-acetic acid; General procedure (A); Step B:; 7-(2,6-Dibromo-pyridin-4-ylsulfanyl)-2-methyl-phenoxy}-acetic acid methyl ester (0.3 g; 0.67 mmol, prepared as described in example 6), cupper iodide (3.8 mg; 0.02 mmol), 4- ethynylbenzylalcohol (266 mg; 2,01 mmol) and bis (triphenylphosphine) (II) chloride (18.8 mg; 0,027 mmol) were added to a dry reaction flask under an atmosphere of nitrogen. Triethylamine (2 ml) and DMF (2 ml) was added and the reaction mixture was reacted at 70 ¡ãC for 10 min in a microwave oven. The reaction mixture was purified by preparative HPLC (method B) to give {4-[2,6-bis-(4-hydroxymethyl-phenylethynyl)-pyridin-4-ylsulfanyl]-2-methyl- phenoxy}-acetic acid methyl ester. Yied: 260 mg; 70 percent. LC-MS (system 1): Rt: 3.02 min.; Mw: 576.4.

The synthetic route of 10602-04-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOVO NORDISK A/S; WO2005/105726; (2005); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.15484-46-5, name is Methyl 2-(hydroxymethyl)acrylate, molecular formula is C5H8O3, molecular weight is 116.12, as common compound, the synthetic route is as follows.Product Details of 15484-46-5

MgI2 (683 mg, 2.45 mmol) was added to anhydrous CH2Cl2 (6 mL), and the mixture was stirred at normal temperature for 45 min. The mixture was cooled to -78 C., and then methyl 2-(hydroxymethyl)acrylate dissolved in anhydrous CH2Cl2 (8 mL) was added thereto. The mixture was further stirred at -78 C. for 30 min, and then isopropyl iodide (417 mg, 24.5 mmol), Bu3SnH (2.57 mg, 8.84 mmol) and Et3B (8.84 mL, 8.84 mmol, 1.0 M/hexane solution) in sequence were slowly added thereto. Immediately after all were added thereto, air (20 mL) was slowly added thereto through a syringe. After the mixture was stirred for 2 hr and 30 min, the reactant was diluted in diethyl ether (120 mL). Silica gel (10 g) was added thereto, and then the resulting mixture was evaporated under reduced pressure. The powder obtained was washed with hexane (500 mL) and extracted with diethyl ether (300 mL), evaporation was performed under reduced pressure, and then column chromatography was used to obtain 150 mg (yield 78%) of the title compound. 1H NMR (300 MHz, CDCl3) d 0.87 (d, J=6.0 Hz, 3H), 0.88 (d, J=5.4 Hz, 3H), 1.32-1.38 (m, 1H), 1.41-1.76 (m, 2H), 2.34 (s, 1H), 2.45-2.86 (m, 1H), 3.68-3.70 (m, 2H), 3.68 (s, 3H); 13C NMR (75 MHz, CDCl3) d 22.16, 22.43, 25.78, 37.86, 45.45, 51.89, 63.38, 162.18, 176.11.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,15484-46-5, Methyl 2-(hydroxymethyl)acrylate, and friends who are interested can also refer to it.

Reference:
Patent; Korea Institute of Science and Technology; MIN, Sun Joon; Cho, Yong Seo; Lee, Jae Kyun; Pae, Ae Nim; Son, Young Wook; US2013/197227; (2013); A1;,
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Synthetic Route of 79418-41-0, Adding some certain compound to certain chemical reactions, such as: 79418-41-0, name is 3-Amino-7-hydroxy-2H-chromen-2-one,molecular formula is C9H7NO3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 79418-41-0.

3-Amino-7-hydroxy-2H-chromen-2-one (3) (0.56 g, 31 mmol) and 2,5-dimethoxybenzaldehyde (0.51 g, 31 mmol) were dissolved in absolute EtOH (10 mL) and refluxed for 2 h, during which time a precipitate formed. After cooling, the solid was collected and washed with an excess of hot EtOH: yellow solid, 0.9 g, 89 %. m.p. 206-208 C; 1H NMR (DMSO-d6): delta 10.53 (br s, 1H, O-H), 9.31 (s, 1H, N=C-Ar), 7.81 (s, 1H, =C-H), 7.54 (d, 1H, Ar-H, J = 8.2 Hz) 7.50 (s, 2H, Ar-H), 7.09 (s, 2H, Ar-H), 6.80 (d, 1H, Ar-H, J = 8.2 Hz), 6.74 (s, 1H, Ar-H), 3.83 (s, 3H, OCH3), 3.75 (s, 3H, OCH3). m/z obsd 348.1154; calcd for C18H15NO5Na 348.08479.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 79418-41-0, 3-Amino-7-hydroxy-2H-chromen-2-one, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Garcia-Beltran, Olimpo; Mena, Natalia; Friedrich, Leidi C.; Netto-Ferreira, Jose Carlos; Vargas, Victor; Quina, Frank H.; Nunez, Marco T.; Cassels, Bruce K.; Tetrahedron Letters; vol. 53; 39; (2012); p. 5280 – 5283;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.109240-30-4, name is 1-(4-Bromophenyl)cyclopropanol, molecular formula is C9H9BrO, molecular weight is 213.0712, as common compound, the synthetic route is as follows.HPLC of Formula: C9H9BrO

1-(4-bromophenyl)cyclopropanol (250 mg, 1.17 mmol), potassium acetate (177 mg, 1.8 mmol), Bis(Pinacolato)Diboron (449 mg, 1.77 mmol), and Dichloro 1,1-bis(diphenylphosphino)ferrocene palladium(II) dichloromethane (44 mg, 0.06 mmol) were added to a flask and system was placed under argon. Reagents were taken up in dioxane (10 mL) and system was again evacuated and placed under argon. Mixture was heated at 100 C. for 17 hours. After cooling to room temperature, mixture was filtered over celite, washing with ethyl acetate. Filtrate was concentrated under reduced pressure and resulting residue was purified via silica gel column chromatography (0-50% ethyl acetate in hexanes) to yield 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropanol 7.63.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,109240-30-4, 1-(4-Bromophenyl)cyclopropanol, and friends who are interested can also refer to it.

Reference:
Patent; Gilead Scientific Systems, Inc.; Cory, Kevin S; Doo, Jimin; Farrand, Julie; Guerrero, Juan A; Katana, Ashley A; Cato, Daryl; Laisaweed, Scott I; Lee, Jiayao; Lingco, John O; Nicolaus, May; Notte, Gregory; Phyen, Hyeoung-Jung; Sangy, Michael; Sumit, Arun C; Adam J, Surayyah; Stephens, Cork L; Venkatraman, Chandrasekar; Watkins, William J; Yang, Jong Yu; Jabloki, Jeff; Jifel, Shiela; Ro, Jennifer; Lee, Sung H; Jao, Chung Dong; Grove, Jeffery; Su, Jianjun; Blomgren, Peter; Mitchell, Scott A; Shyung, Jin Ming; Chandrasekar, Jayaraman; (460 pag.)KR2016/37198; (2016); A;,
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