Month: December 2020

355-80-6, Adding a certain compound to certain chemical reactions, such as: 355-80-6, 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 355-80-6, blongs to alcohols-buliding-blocks compound.

Example 8Preparation of 5-(2,2,2-trifluoroethoxy)-1,1,2,2,3,3,4,4-octafluoropentane; H(CF2CF2)2CH2OCH2CF3 2,2,3,3,4,4,5,5-Octafluoropentan-1-ol (50 g, 0.215 mol), 2,2,2-trifluoroethyl trifluoromethanesulfonate (50 g, 0.215 mol, obtained from Synquest Labs, Inc., Alachua, Fla.), potassium carbonate (29.7 g, 0.215 mol) and 175 g of acetone (solvent) were combined in a 600-mL Parr pressure reactor. After degassing, the reactor was sealed and the mixture was heated to 75 C. with vigorous stirring for 16 hours. After cooling, the reactor was opened and the contents filtered to remove the insoluble salts. The acetone was removed by rotary evaporation. To this residue was then added an excess of water and the product azeotropically distilled using a Dean Stark trap to give after phase separation and water washing 60.4 g crude product. The yield at this stage by GC analysis was 50 percent. The product was distilled at atmospheric pressure and the distillation cuts greater than 138 C. were combined with the pot and subsequently treated with LiCl (15 g) in N,N-dimethylformamide (250 mL) at 50 C. as described in Example 4 to remove the residual 2,2,2-trifluoroethyl trifluoromethanesulfonate. The product was then distilled through the concentric tube column to give the product ether, boiling point=138-143 C. in 95.9 percent purity. The structure was consistent with GC/MS and 1H NMR analysis.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,355-80-6, its application will become more common.

Reference:
Patent; Flynn, Richard M.; Bulinski, Michael J.; Costello, Michael G.; US2010/108934; (2010); A1;,
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616-29-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 616-29-5, name is 1,3-Diaminopropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows.

To a vigorously stirred ethanolic solution of salicylaldehyde (0.106 mL, 1 mmol) an ethanolic solution (20 mL) of 1,3-diamino-2-propanol (0.046 g, 0.5 mmol) was added dropwisely. The solution turned to light yellow and the mixture refluxed for 4 h. The resulting yellow powder was collected by filtration, washed with cold ethanol and ether and dried in the air ( Scheme 1 ). L2 was synthesized in order to compare with L1 from the point of view of the effect of substituent on DNA-binding measurements, cleavage activity, and cytotoxicity. Yield >70%; m.p. >250omicronC; F.W: 298.20, Color: yellow. Anal. calcd for C17H18N2O3: C, 68.44; H, 6.08; N,9.39%. Found: C, 68.04; H, 5.73, N, 9.56%. FT-IR (KBr, cm-1): 3394 (nuOH), 2893 (nuC-H), 1635 (nuC=N). UV-Vis (H2O): lambdamax (nm) = 386, 324. 1HNMR (250 MHz, DMSO-d6, room temperature): delta(ppm) = 13.52 (s, 2H, OH), 8.50 (s, 2H, HC=N), 7.42-6.85 (m, 8H, ArH), 5.17 (s, 1H, CHOH), 3.97 (s, 1H, CHOH), 3.76 (d, 2H, CH2), 3.57 (d, 2H, CH2).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 616-29-5, 1,3-Diaminopropan-2-ol.

Reference:
Article; Asadi, Zahra; Nasrollahi, Neda; Journal of Molecular Structure; vol. 1147; (2017); p. 582 – 593;,
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Adding some certain compound to certain chemical reactions, such as: 764-48-7, name is Ethylene Glycol Vinyl Ether, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 764-48-7. 764-48-7

Intermediate 2; O-(2-(vinyloxy)ethyl)hydroxylamine; Step A: 2-(2-(vinyloxy)ethoxy)isoindoline-1,3-dione To a solution of 2-(vinyloxy)ethanol (20.4 mL, 227 mmol), triphenylphosphine (59.5 g, 227 mmol), and N-hydroxyphthalimide (37.0 g, 227 mmol) in THF (450 mL) was added DEAD (35.9 mL, 227 mmol) at 0 C. under a N2 atmosphere. After stirring for 16 h at room temperature, the reaction mixture was concentrated in vacuo. The residue was filtered, washed with chloroform and the filtrate was concentrated in vacuo. The residue was purified by column chromatography on SiO2 (Hex: EtOAc=2:1) to give 2-(2-(vinyloxy)ethoxy)isoindoline-1,3-dione (32.5 g, 61.4%) as a yellow solid. 1H NMR (CDCl3, Varian 400 MHz) delta 4.04-4.08 (3H, m), 4.19 (1H, dd, J=14.4, 2.2 Hz), 4.45-4.48 (2H, m), 6.47 (1H, dd, J=14.0, 6.8 Hz), 7.53-7.78 (2H, m), 7.80-7.87 (2 m, m).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 764-48-7.

Reference:
Patent; CHEMIZON, A DIVISION OF OPTOMAGIC CO., LTD.; US2012/238599; (2012); A1;,
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870-72-4, Adding a certain compound to certain chemical reactions, such as: 870-72-4, Hydroxymethanesulfonic Acid Sodium Salt, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 870-72-4, blongs to alcohols-buliding-blocks compound.

EXAMPLE 4 [0188] 422 parts of 4-(beta-sulfatoethylsulfonyl)aniline are suspended in 1000 parts of ice-water and 270 parts of 30% hydrochloric acid and diazotized by dropwise addition of 260 parts of 40% sodium nitrite solution. After excess nitrite has been removed with sulfamic acid solution, the diazo suspension obtained is admixed with an aqueous solution of 166.5 parts of 4-hydroxy-7-(sulfomethylamino)naphthalene-2-sulfonic acid (obtained by reaction of 119.5 parts of 7-amino-4-hydroxynaphthalene-2-sulfonic acid with 75 parts of formaldehyde sodium bisulfite in an aqueous medium at pH 5.5-6 and 45 C.) and adjusted to pH 1.5 with solid sodium bicarbonate. After the acidic coupling has ended, this reaction mixture has added to it an aqueous solution of 335 parts of the second coupling component (18-1) and is adjusted to and maintained at pH 5-6 with sodium carbonate below 25 C. [C00035] [00035] [0189] The 50:50 mixture of the two dyes (1-4) and (11-3) which has formed after the coupling reaction has ended can be isolated by evaporation under reduced pressure or by spray drying. [C00036] [00036] [0190] The resulting dye mixture according to the present invention dyes cotton in red shades.; EXAMPLE 11 [0206] 281 parts of 4-(beta-sulfatoethylsulfonyl)aniline are suspended in 700 parts of ice-water and 180 parts of 30% hydrochloric acid and diazotized by dropwise addition of 173 parts of 40% sodium nitrite solution. After excess nitrite has been removed with sulfamic acid solution, the diazo suspension obtained is admixed with an aqueous solution of 83 parts of 4-hydroxy-7-(sulfomethylamino)naphthalene-2-sulfonic acid (obtained by reaction of 60 parts of 7-amino-4-hydroxynaphthalene-2-sulfonic acid with 37.5 parts of formaldehyde sodium bisulfite in an aqueous medium at pH 5.5-6 and 45 C.) and adjusted to pH 1.5 with solid sodium bicarbonate. After the acidic coupling has ended, this reaction mixture has added to it an aqueous solution of 111 parts of 4-amino-phthalene-1-sulfonic acid as the second coupling component and is adjusted to and maintained at pH 5-6 with sodium carbonate below 25 C. After the coupling reaction has ended, the reaction mixture is admixed with 73 parts of the golden yellow azo dye of the formula (Ga-1) and the resulting 42:46:12 mixture of the three azo dyes (I-4), (II-6) and (Ga-1) is isolated by spray drying. [C00046] [00046] [0207] The resulting dye mixture according to the present invention provides orange dyeings and prints on cotton for example under the dyeing conditions customary for reactive dyes.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,870-72-4, its application will become more common.

Reference:
Patent; DyStar Textilfarben GmbH & Co. Deutschland KG; US2005/34253; (2005); A1;,
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The common heterocyclic compound, 616-29-5, name is 1,3-Diaminopropan-2-ol, molecular formula is C3H10N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route. 616-29-5

Example 1 11- {[tert-Butyl (dimethyl) silyl] oxy}-9- (methylsulfonyl)-9, 10,11, 12-tetrahydro-8H [1, 4] diazepino [1′, 2′ : 1, 2] imidazo [4,5-c] quinolin-6-amine Part A Under a nitrogen atmosphere, a solution of di-tert-butyl dicarbonate (145. 35 g, 665.98 mmol) in 1,4-dioxane (400 mL) was added dropwise with stirring to a solution of 2-hydroxy-1, 3-diaminopropane (300.00 g, 332.85 mmol) in methanol (500 mL) over a period of six hours. The reaction was stirred overnight at ambient temperature and then concentrated under reduced pressure. The residue was dissolved in 10% citric acid in water, and additional citric acid was added to adjust the solution to pH 4. The resulting solution (1-1.5 L) was washed with dichloromethane (3 x 500 mL) and then adjusted to pH 12 with the addition of 50% aqueous sodium hydroxide. The basic solution was extracted with chloroform (7 x 500 mL), and the combined extracts were concentrated under reduced pressure and dried overnight under high vacuum to provide 108. 19 g of tert-butyl 3-amino-2-hydroxypropylcarbamate as a white solid.

The synthetic route of 616-29-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; 3M INNOVATIVE PROPERTIES COMPANY; WO2005/66172; (2005); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 124-68-5, name is 2-Amino-2-methyl-1-propanol. This compound has unique chemical properties. The synthetic route is as follows. 124-68-5

N-methyl-2-amino-2-methyl-propan-1 -ol (4)2-Amino-2-methylpropanol (3) (10 g, 0.11 mol), Na2CO3 (0.41 g), NaHCO3 (0.41 g) and 3:1 dioxane/water (41 ml) were stirred together at 00C. Boc anhydride (29.4 g, 0.13 mol) was added slowly and the reaction was stirred at room temperature for 6 h. The salts formed were filtered and washed with DCM. The filtrate was diluted with water (50ml) and extracted with DCM (3 x 50 ml), dried (Na2SO4) and evaporated to dryness, giving a white solid. This was dissolved in THF (100 ml) and added dropwise to a mixture of lithium aluminium hydride (12.7 g, 0.33 mol) in THF (200 ml). The mixture was heated to reflux overnight then cooled to room temperature. Water (15 ml) was added slowly with ice-cooling followed by 4 M NaOH (15 ml), and then more water (45 ml). The white solids were filtered, washed with THF, and the filtrate was evaporated to dryness, giving a pink solid (8.9 g, 77%). 1H NMR (400 MHz, CDCI3): 0.97 (6H, s), 2.24 (3H, s), 3.26 (2H, s); 13C NMR (100 MHz, CDCI3): 23.27, 28.41 , 53.62, 68.26.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 124-68-5, 2-Amino-2-methyl-1-propanol.

Reference:
Patent; BIOCOPEA LIMITED; BANNISTER, Robin Mark; WO2010/103312; (2010); A1;,
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100-37-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100-37-8, name is 2-(Diethylamino)ethanol, molecular formula is C6H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Under air atmosphere, a reaction tube was charged with disulfide (0.2 mmol), Tertiary amine (0.4 mmol), I2 (0.4 mmol) Na2CO3 (0.4 mmol) and DMSO (2 mL). The vessel was sealed and heated at 100 C (oil bath temperature) for 24 h and then cooled to room temperature. The reaction mixture was washed with saturated Na2S2O3(2 x 15 mL) and then brine (1 x 15 mL). After the aqueous layer was extracted with ethyl acetate, the combined organic layers were dried over anhydrous Na2SO4 and evaporated under vacuum. The residue was purified by flash column chromatography (hexane/ethyl acetate) to afford the desired products.

The chemical industry reduces the impact on the environment during synthesis 100-37-8, I believe this compound will play a more active role in future production and life.

Reference:
Letter; Gao, Xu-Hong; Xu, Wei; Zhang, Xing-Guo; Deng, Chen-Liang; Synlett; vol. 28; 7; (2017); p. 841 – 846;,
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623-50-7, Adding a certain compound to certain chemical reactions, such as: 623-50-7, Ethyl 2-hydroxyacetate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 623-50-7, blongs to alcohols-buliding-blocks compound.

Step 1-Synthesis of ethyl 4-oxotetrahydrofuran-3-carboxylate (ge). NaH (60%, 4.6 g, 116 mmol) was suspended in ether (200 mL) and cooled in ice-bath. To this suspension was added ethyl glycolate (10 mL, 100 mmol) dropwise under N2. The resulting white slurry was stirred at rt for 45 min. Ether was removed in vacuo to give white solid. It was suspended in DMSO (130 mL), cooled in ice-bath, and ethyl arcylate (13.7 mL, 127 mmol) was added dropwise. The resulting yellow mixture was stirred at rt overnight. The reaction solution was poured into 10% aq. HCl (500 mL) slowly. It was extracted with ether (3¡Á). The combined ether extract was washed with brine, dried over MgSO4, filtered, concentrated in vacuo to give 14 g (80%) of (ge) as clear yellow liquid. It was carried on without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,623-50-7, its application will become more common.

Reference:
Patent; Genentech, Inc.; US2010/331305; (2010); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2854-16-2, name is 1-Amino-2-methylpropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. 2854-16-2

Example 15. 6-Bromo-8-cvclopentyl-2-(2-hvdroxy-2-methylpropylamino)-4-methylpyridof2.3-ty|pyrimidin- 7(betaH)-one; To a solution of 6-bromo-8-cyclopentyl-4-methyl-2-(methylsulfinyl)pyrido[2,3-cdpyrimidin-7(8/-/)- one (600 mg, 1.62 mmol) and 1-amino-2-methylpropan-2-ol (294 mg, 2.34 mmol) in dioxane (6 ml_) was added triethylamine (1.2 ml_, 8.6 mmol). The mixture was then heated at 110 0C in a sealed tube for 1 h. The solution was poured into brine and extracted with ethyl acetate. The organic was dried (anhydrous sodium sulfate), filtered and concentrated to dryness. The crude product was purified by silica gel flash chromatography to give the title compound as a solid (565 mg, 88percent).LRMS: 395, 397 (M+H)+.1H NMR (CDCI3, 400 MHz): 8.07 (1 H, s), 5.91-6.13 (1 H, m), 5.46-5.90 (1 H, m), 3.52 (2H, d, J = 6.32 Hz), 2.54 (3H, s), 2.17-2.43 (2H, m), 1.95-2.16 (2H, m), 1.76-1.95 (2H, m), 1.56-1.74 (3H, m), 1.30 (6H, s).

Statistics shows that 2854-16-2 is playing an increasingly important role. we look forward to future research findings about 1-Amino-2-methylpropan-2-ol.

Reference:
Patent; PFIZER PRODUCTS INC.; WO2008/32162; (2008); A1;,
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2854-16-2, Adding some certain compound to certain chemical reactions, such as: 2854-16-2, name is 1-Amino-2-methylpropan-2-ol,molecular formula is C4H11NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2854-16-2.

Preparation of compound 2-4 To a solution of 2-3 (10 g, 41 mmol) and TEA (5 g, 49 mmol) in DCM was added 2-a (3 g, 34 mmol) dropwise. The mixture was stirred for 12 hrs at 40¡ãC. The solution was cooled down to r.t., and washed with brine, dried over anhydrous Na2SO4 and filtered. The filtration was concentrated and crude product was obtained. Further purification by silica gel column chromatography (PE: EA=1: 1) afforded 6.0 g desiredproduct, yield 50percent.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2854-16-2.

Reference:
Patent; ASCEND BIOPHARMACEUTICALS PTY LTD; PIETERSZ, Geoffrey, Alan; WO2013/67597; (2013); A1;,
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