Month: December 2020

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2615-15-8, name is 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol. This compound has unique chemical properties. The synthetic route is as follows. 2615-15-8

j00479j A solution of 3,6,9,12,15-pentaoxaheptadecane-1,17-diol (7 g, 24.8 mmol) in DCM (50 mL) was cooled to 0 C and charged with silver oxide (8.60 g, 37.2 mmol), potassium iodide (822 mg, 4.95 mmol) and tosyl chloride (5.10 g, 27.17 mmol) and stirred at0C for 4 h. The reaction mixture was diluted with iN HC1 solution (15 mL), the organic layers was separated and dried over anhydrous Na2SO4, filtered and concentrated in vacuo resulting in a crude compound which was purified by chromatography on silica gel, eluting with 1-3% methanol in DCMto give 7.30 g, 67% yield of the title compound as colorless oil. ?H NMR (400 MHz, DMSO-d6): oe = 7.79 (d, J= 8.43 Hz, 2H), 7.48 (d, J= 7.98 Hz, 2H), 4.56 (t, J= 5.54 Hz, 1H), 4.08 -4.14 (m, 1H), 3.43 -3.59 (m, 20H), 3.41 (d, J= 5.32 Hz, 2H), 3.39 (s, 1H), 2.42 (s, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2615-15-8, 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol, and friends who are interested can also refer to it.

Reference:
Patent; COFERON, INC.; FOREMAN, Kenneth, W.; JIN, Meizhong; WANNER, Jutta; WERNER, Douglas, S.; WO2015/106292; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

108-82-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 108-82-7, name is 2,6-Dimethylheptan-4-ol. This compound has unique chemical properties. The synthetic route is as follows.

A solution of Intermediate 16 (13-oxo-pentacosane-l,25-dioic acid) (1.01 g), 4-dimethylaminopyridine (0.86 g), N-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride (0.95 g) and 2,6- dimethylheptan-4-ol (1.92 g) in dichloromethane (20 mL) was stirred at room temperature overnight. The solution was washed with diluted hydrochloric acid, dried over anhydrous magnesium sulfate, filtered and the solvent removed. The residue was passed down a silica gel (20 g) column using dichloromethane as the eluent, yielding 0.40 g of product.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 108-82-7, 2,6-Dimethylheptan-4-ol.

Reference:
Patent; ALNYLAM PHARMACEUTICALS, INC.; ANSELL, Steven, Michial; DU, Xinyao; WO2013/86322; (2013); A1;,
Alcohol – Wikipedia,
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In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 575-03-1 as follows., 575-03-1

General procedure: The corresponding coumarin derivatives (4.21mmol) 5a-k and potassium carbonate (0.872 g, 6.31 mmol) were suspended in dry acetone, and then the corresponding dibromoalkyl derivative (84.12 mmol) was added. The mixture was refluxed for 6 h. After cooling to room temperature, the solid was filtered and washed with acetone. The filtrate was concentrated under reduced pressure and purified by column chromatography using petroleum ether/ethy actate (5 : 1 to 8:1) as eluent to get the intermediates of 6a-n

The chemical industry reduces the impact on the environment during synthesis 575-03-1, I believe this compound will play a more active role in future production and life.

Reference:
Article; He, Qi; Liu, Jing; Lan, Jin-Shuai; Ding, Jiaoli; Sun, Yongbing; Fang, Yuanying; Jiang, Neng; Yang, Zunhua; Sun, Liyuan; Jin, Yi; Xie, Sai-Sai; Bioorganic Chemistry; vol. 81; (2018); p. 512 – 528;,
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2615-15-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2615-15-8, name is 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol, molecular formula is C12H26O7, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A solution of sodium hydroxide (5.48 g, 137 mmol) in water (30 mL) was added to a solution of PEG compound (904 mmol) in THF (30 mL). The resulting mixture was cooled to 0 C and a solution of p-toluenesulfonyl chloride (16.6 g, 87.4 mmol) in THF (100 mL) was slowly added under stirring for 2 hours. After stirring at 0 C for 3 hours, the reaction mixture was poured onto an ice/water mixture (500 mL). The organic layer was separated, and the aqueous layer was extracted with dichloromethane (3 ¡Á 200 mL). The combined organic layers were washed twice with water (100 mL), dried with MgSO4 and concentrated in vacuo.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2615-15-8, 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Kachbi-Khelfallah, Souad; Monteil, Maelle; Cortes-Clerget, Margery; Migianu-Griffoni, Evelyne; Pirat, Jean-Luc; Gager, Olivier; Deschamp, Julia; Lecouvey, Marc; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 1366 – 1370;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

6338-55-2, Adding a certain compound to certain chemical reactions, such as: 6338-55-2, 2-(2-(2-Aminoethoxy)ethoxy)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 6338-55-2, blongs to alcohols-buliding-blocks compound.

2-(2-(2-aminoethoxy)ethoxy)ethanol (0.6 g, 4.062 mmol) was dissolved in acetonitrile (25 ml). The solution was cooled to 0C and Et3N (1.13 ml, 8.12 mmol, 2 eq.) was added followed by Boc2O (0.268 g, 1.23 mmol). The reaction was followed by TLC and stirred overnight at room temperature. Water (15 ml) was added and the solution was extracted with EtOAc (3×30 ml), brine was used to help separating the two layers (5 ml) and also (30 ml) for washing. The combined organic layers were dried over Na2SO4, filtered and concentrated under reduced pressure. The crude product was purified by flash chromatography on silica gel (CH2Cl2/MeOH, 96:4) to give the title compound as a yellow oil (0.670 g, 66 % yield)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6338-55-2, its application will become more common.

Reference:
Article; Simonin, Jonathan; Vernekar, Sanjeev Kumar V.; Thompson, Andrew J.; Hothersall, J. Daniel; Connolly, Christopher N.; Lummis, Sarah C.R.; Lochner, Martin; Bioorganic and Medicinal Chemistry Letters; vol. 22; 2; (2012); p. 1151 – 1155;,
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647-42-7, Adding a certain compound to certain chemical reactions, such as: 647-42-7, 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 647-42-7, blongs to alcohols-buliding-blocks compound.

General procedure: Dichloro-s-tetrazine (1 mmol) and fluorinated alcohol (1 mmol) were dissolved in anhydrous dichloromethane (10 mL). 2,4,6-collidine (1 mmol) was added dropwise at room temperature in the solution, and the mixture was stirred for 12 h under N2 atmosphere.The solvent was evaporated and the residue was passed through a column of silica (2/8 dichloromethane/petroleum ether v/v) to give compound 2 as a pink solid, with a ?yellow? fluorescence on TLC (using a standard laboratory UV lamp with a broad band centred at 365 nm).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,647-42-7, its application will become more common.

Reference:
Article; Ben Chaabane, Radhia; Guermazi, Refka; Clavier, Gilles; Audebert, Pierre; Hedhli, Ahmed; Dyes and Pigments; vol. 108; (2014); p. 64 – 69;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 106-28-5, name is (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-ol, the common compound, a new synthetic route is introduced below. 106-28-5

L-(+)-Diethyltartrate (428 muL, 2.5 mmol, 12.5 mol %) and 4A molecular sieves(2g, 0.1g/mmol) were placed in a 50 mL round bottom flask under a stream of argon.CH2Cl2 (20 mL) was added at room temperature, followed by Ti(Oi-Pr)4 (600 muL, 2mmol, 10 mol %). The mixture was stirred vigorously at room temperature for 20 min.tert-Butylhydroperoxide (4.54 mL, ~25 mmol, 125 mol%, 5-6 M in decane) was addedand the mixture was stirred 5 min at room temperature. The mixture was cooled in aCH3CN / dry ice bath. The temperature was maintained below -40 C. Farnesol (5.06mL, 20 mmol, 100 mol %) was added and stirred in the CH3CN / dry ice bath for 10 h.The mixture was placed in the freezer overnight. The next day citric acid monohydrate(420 mg, 2 mmol, 10 mol%) was dissolved in 1:1 acetone / diethylether (~5 mL) and thesolution was added to the reaction mixture. The mixture was stirred vigorously for 20min at room temperature. Celite was added to the mixture and stirred vigorously for 1min. The slurry was filtered through a thick pad of celite and the celite was washed withEt2O. The clear filtrate was washed with saturated Na2S2O3 and then dried with MgSO4.Column chromatography isolated 4.53 g of S1 (95% yield). The enantiomeric excess wasdetermined by HPLC of the benzoate to be 87%. 1H NMR (400 MHz, CDCl3):delta 5.10 (m, 2H), 3.84 (ddd, J = 4.3, 7.5, 12.0 Hz, 1H), 3.70 (ddd, J = 4.9, 6.7, 11.8 Hz,1H), 2.99 (dd, J = 4.3, 6.7 Hz, 1H), 2.16-1.94 (m, 6H), 1.71 (m, 1H), 1.69 (s, 3H), 1.614(s, 3H), 1.608 (s, 3H), 1.48 (m, 1H), 1.32 (s, 3H).13C NMR (125 MHz, CDCl3):delta 136.0, 131.6, 124.4, 123.3, 63.2, 61.6, 61.4, 39.8, 38.7, 26.8, 25.9, 23.8, 17.9, 17.0,16.2.IR (NaCl, thin film): 3422, 2919, 1456, 1384, 1033 cm-1.HR-MS (ESI) m/z calcd for C15H26O2 [M+Na]+: 261.1825, found 261.1830.[alpha]20D = -4.2 (c = 1.9, CHCl3). Chiral HPLC analysis: Analysis was performed on the corresponding benzoate (BzCl,Et3N, DMAP, CH2Cl2): (Chiralcel AD-H, hexanes:2-propanol, 99:1, 1.0 mL/min):tR(2S,3S) = 7.3 min; tR(2R,3R) = 8.1 min. The enantiomeric excess was determined to be87%.

Statistics shows that 106-28-5 is playing an increasingly important role. we look forward to future research findings about (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-ol.

Reference:
Article; Underwood, Brian S.; Tanuwidjaja, Jessica; Ng, Sze-Sze; Jamison, Timothy F.; Tetrahedron; vol. 69; 25; (2013); p. 5205 – 5220;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 6338-55-2, 2-(2-(2-Aminoethoxy)ethoxy)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 6338-55-2, blongs to alcohols-buliding-blocks compound. 6338-55-2

To a 250-mL round-bottom flask was added 2-[2-(2- aminoethoxy )ethoxy ] ethan- 1 -ol (5.3 g, 35.53 mmol, 2 equiv), CH2CI2 (50 mL), triemylamine (5.37 g, 53.07 mmol, 3 equiv), and INT-L3 (R1 = H, 5 g, 17.7 mmol, 1 equiv). The resulting solution was stirred overnight. The reaction was then quenched by the addition of 50 mL of water and extracted with 3 x 50 mL of ethyl acetate. The organic layers were combined, dried over anhydrous sodium sulfate, filtered, and concentrated under vacuum The residue was applied onto a silica gel column with CftCh/methanol (0-55%) providing 6.4 g (92%) of 2-[2-(2-[[4-(benzyloxy)benzene]sulfonamido]ethoxy)emoxy]ethan-l-ol (I T-T1) as a white solid.

With the rapid development of chemical substances, we look forward to future research findings about 6338-55-2.

Reference:
Patent; ARDELYX, INC.; DRAGOLI, Dean; DOTSENKO, Irina; LEWIS, Jason; (439 pag.)WO2018/129552; (2018); A1;,
Alcohol – Wikipedia,
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1074-16-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1074-16-4, name is 2-(2-Bromophenyl)ethanol, the common compound, a new synthetic route is introduced below.

A solution of 2-bromophenethylalcohol (10 g, 50 mmol) in thionyl chloride (45 ml_) was treated with dimethylformamide (0.1 ml_) and heated to reflux for 6 hours. The reaction mixture was cooled to 00C, quenched by the addition of H2O (100 ml_), extracted with ethyl ether (250 ml_), dried (Na2SO4), and evaporated to provide 2- bromophenethylchloride (9.0 g, 82%) as a yellow oil:HPLC purity 99.2% at 210-370 nm, 10.4 minutes; Xterra RP18, 3.5u, 150 x 4.6 mm column, 1.2 mL/minutes, 85/15-5/95 (ammonium formate buffer pH = 3.5/ACN+MeOH) for 10 minutes, hold 4 minutes.

Statistics shows that 1074-16-4 is playing an increasingly important role. we look forward to future research findings about 2-(2-Bromophenyl)ethanol.

Reference:
Patent; WYETH; WO2008/73956; (2008); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

111-90-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 111-90-0, name is Diethylene Glycol Monoethyl Ether. This compound has unique chemical properties. The synthetic route is as follows.

The 4,7-dichloroquinazoline used as a starting material was obtained as follows:- A mixture of 4-chloroanthranilic acid (17.2 g) and formamide (10 ml) was stirred and heated to 130C for 45 minutes and to 175C for 75 minutes. The mixture was allowed to cool to approximately 100C and 2-(2-ethoxyethoxy)ethanol (50 ml) was added. The solution so formed was poured into a mixture (250 ml) of ice and water. The precipitate was isolated, washed with water and dried. There was thus obtained 7-chloroquinazolin-4-one (15.3 g, 85%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 111-90-0, Diethylene Glycol Monoethyl Ether.

Reference:
Patent; ZENECA LIMITED; EP520722; (1992); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts