Month: December 2020

3360-41-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3360-41-6, name is 4-Phenylbutan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

Triphenylphosphine (2.72 g, 10.4 mmol) was added to the 4-phenyl-1-butanol (1.2 g, 8.0 mmol) in CCl4 (10 mL) at room temperature under atmosphere of argon, and the mixture was refluxed for 1 h. The reaction quenched with water and extracted with hexane. The extracts were washed with brine, dried over MgSO4, and concentrated under reduced pressure. The residue was purified by column chromatography with hexane/AcOEt (100:1) to give (4-chlorobutyl)benzene (5d) as a colorless oil in 85% yield. The analytical data were identical with those of a literature compound.10 IR (neat): nu = 2940 (CH2), 699 (Alkyl-Cl); 1H NMR (500 MHz, CDCl3): delta = 1.72-1.86 (4H, m), 2.64 (2H, t, J = 7.2 Hz), 3.54 (2H, t, J = 6.3 Hz), 7.15-7.21 (3H, m), 7.25-7.31 (2H, m); 13C NMR (125 MHz, CDCl3): delta = 28.5, 32.1, 35.1, 44.9, 125.9, 128.4, 141.8; MS (EI) m/z 168 ([M]+).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 3360-41-6, 4-Phenylbutan-1-ol.

Reference:
Article; Hatae, Noriyuki; Kujime, Eiko; Yano, Keigo; Kizuka, Mami; Ashida, Rina; Choshi, Tominari; Nishiyama, Takashi; Okada, Chiaki; Iwamura, Tatsunori; Yoshimura, Teruki; Heterocycles; vol. 97; 1; (2018); p. 560 – 568;,
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2516-33-8, Adding some certain compound to certain chemical reactions, such as: 2516-33-8, name is Cyclopropylmethanol,molecular formula is C4H8O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2516-33-8.

To a mixture of 2-cyclopropyl-methanol (6.15 g) and DMF (12 mL) was added NaH (60% in mineral oil, 1 .5 g) at 0C. After stirring for 4 hours at RT the mixture was diluted with DMF (5 mL) and 5-bromo-2-fluoro-pyridine (6.00 g) was slowly added keeping the reaction temperature below 300C. After 30 minutes at RT the mixture was heated to 130C for 1 hour by microwave irradiation. After cooling to RT the mixture was diluted with EA and washed with water (3 x). The organic phase was dried (Na2SO4) andconcentrated. The residue was purified by SGC to provide the subtitle compound. MS ESI: mlz = 228 [M+H].

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2516-33-8.

Reference:
Patent; SANOFI; SCHWINK, Lothar; BUNING, Christian; GLOMBIK, Heiner; GOSSEL, Matthias; KADEREIT, Dieter; HALLAND, Nis; LOHMANN, Matthias; POeVERLEIN, Christoph; RITTER, Kurt; WO2015/150564; (2015); A1;,
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617-94-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 617-94-7, name is 2-Phenyl-2-propanol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Bi(OTf)3 (1.0 mol%) was added to a solution of the appropriate secbenzylalcohol (1.0 equiv) and TMSN3 (1.2 equiv) in CH2Cl2 (4.0mL/mmol) at r.t. When the reaction was complete (TLC), the solventwas removed and the crude material was purified by column chromatography.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 617-94-7, 2-Phenyl-2-propanol.

Reference:
Article; Tummatorn, Jumreang; Thongsornkleeb, Charnsak; Ruchirawat, Somsak; Thongaram, Phanida; Kaewmee, Benyapa; Synthesis; vol. 46; 11; (2015);,
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404-91-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 404-91-1, name is 2-(3-Fluoro-4-methoxyphenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of resin bound triphenyl phosphine (polystyrene 2% cross linking, loading = 3 mmol/g, 3 g, 9 mmol) and imidazole (0.48 g, 7.1 mmol) in DCM (30 ml.) cooled on an ice bath was drop wise added Br2 (1.13 g, 7.1 mmol), whereupon a solution of 4-(2-hydroxy- ethyl)-2-fluoro-1-methoxy-benzene (1.0g, 5.88 mmol) in DCM (5 ml.) was added. The cooling bath was removed and the reaction mixture was stirred for 16 hs before the resin was filtered off. The resin was washed with DCM and the filtrate was concentrated in vacuo. The residue was purified using column chromatography (SiO2, heptane-EtAOc 95:5) to give 0.82 g of 4- (2-bromo-ethyl)-2-fluoro-1-methoxy-benzene

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 404-91-1, 2-(3-Fluoro-4-methoxyphenyl)ethanol.

Reference:
Patent; NOVO NORDISK A/S; WO2008/84044; (2008); A1;,
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355-80-6, Adding a certain compound to certain chemical reactions, such as: 355-80-6, 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 355-80-6, blongs to alcohols-buliding-blocks compound.

General procedure: A solution of 2-chloro-1,3,2-dioxaphospholane 1 or 2 or 2-chloro-1,3,2-dioxaphosphinane 6 or 7 in 10 mL of hexane was added dropwise with stirring over a period of 2 h to a solution of 0.05 mol of polyfluoroalkanol 3 or 4 and 6.1 g (0.06 mol) of triethylamine in 80 mL of hexane, maintaining the temperature at -10 to -5C. Triethylamine hydrochloride separated from the solution as a white solid. The cooling bath was removed, and the mixture was stirred for 3 h at room temperature and left overnight. The precipitate was filtered off and washed with hexane (3*20 mL). The filtrate was combined with the washings, the solvent was distilled off under reduced pressure, and the residue was distilled in a vacuum.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,355-80-6, its application will become more common.

Reference:
Article; Gusarova; Verkhoturova; Arbuzova; Kazantseva; Albanov; Nalibaeva; Bishimbaeva; Apartsin; Kireeva; Trofimov; Russian Journal of General Chemistry; vol. 88; 4; (2018); p. 705 – 712; Zh. Obshch. Khim.; vol. 88; 4; (2018); p. 623 – 630,8;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 39590-81-3, name is 1,1-Bis(Hydroxymethyl)cyclopropane. This compound has unique chemical properties. The synthetic route is as follows. 39590-81-3

A. Iodination of Diol 6 to Prepare 7a [0228] Triphenylphospine (257.2 g) and imidazole (66.7 g) were charged to a reactor. DCM (490 mL) was charged, agitation was initiated and the solution was cooled to 0 C. Iodine (249.2 g) was added as a solid portion-wise over 1 h while maintaining the internal temperature below 10 C. Upon completion of the addition, a solution of 6 (50 g) in DCM (113 mL) was slowly charged to the reactor over 0.5 h while maintaining the internal temperature below 10 C. After stirring for 2.5 h, an aqueous solution of NaCl (25 g) in water (225 mL) was charged to the reactor. Following phase separation, the bottom organic layer was diluted with n-heptane (550 mL). The organic phase was washed with an aqueous solution of sodium sulfite (21 g) in water (190 mL). Following layer separation, the organic phase was concentrated to 600 mL via vacuum distillation. Additional n-heptane (550 mL) was charged, and the mixture was again concentrated to 600 mL via vacuum distillation. The resulting slurry was filtered over a silica gel plug (85 g) that had been slurry packed with n-heptane. The silica gel plug was rinsed with additional n-heptane (1 L), and the filtrate was then concentrated via vacuum distillation to provide the desired product 7a as a colorless liquid (114 g, 70%). 1H NMR (400 MHz, CDCl3) delta 3.33 (s, 2H), 0.95 (s, 2H). 13C NMR (75 MHz, CDCl3): 19.1, 22.7, 26.0.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 39590-81-3, 1,1-Bis(Hydroxymethyl)cyclopropane.

Reference:
Patent; Scott, Robert William; Wang, Fang; Shi, Bing; Mogalian, Erik; US2013/324496; (2013); A1;,
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In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 624-95-3 as follows., 624-95-3

2.24 g (51.3 mmol) of 55 wt% sodium hydride was suspended in 100 ml of tetrahydrofuran. 4.24 g (41.5 mmol) of 3,3-dimethylbutanol was added dropwise to the suspension under ice cooling, and the mixture was stirred at room temperature for 15 minutes. To this was added dropwise 20 ml of a tetrahydrofuran solution of 5.0 g (37.7 mmol) of 2-chloro-5-fluoropyrimidine, followed by stirring at room temperature overnight. A saturated aqueous solution of ammonium chloride was added thereto, and the mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, and the inorganic matter was removed by filtration. The filtrate was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography to obtain 4.40 g (22.2 mmol, yield 59%) of 2- (3,3-dimethylbutoxy) -5-fluoropyrimidine.

The chemical industry reduces the impact on the environment during synthesis 624-95-3, I believe this compound will play a more active role in future production and life.

Reference:
Patent; NIPPON SODA COMPANY LIMITED; ITO, SYUICHI; AMANO, TOMOHIRO; IPPOSHI, JUNJI; KOUBORI, SHINYA; (44 pag.)JP2016/30742; (2016); A;,
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Adding a certain compound to certain chemical reactions, such as: 440-60-8, (Perfluorophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 440-60-8, blongs to alcohols-buliding-blocks compound. 440-60-8

EXAMPLE 1 This Example illustrates the preparation of 2-methyl-3,4,5,6-tetrafluorobenzyl alcohol. A solution of methyl bromide (9.6 g) in dry tetrahydrofuran (25 cm3) was added dropwise in a stirred mixture of magnesium turnings (5.0 g), dry tetrahydrofuran (50 cm3) and a small crystal of iodine at the ambient temperature (ca. 22 C.). When the addition was complete the mixture was stirred for a further 1 hour at the ambient temperature and the solution of methyl magnesium bromide thus formed was then added dropwise to a stirred solution to pentafluorobenzyl alcohol (17.8 g) in tetrahydrofuran (50 cm3) whilst the temperature was maintained at 30 C. When the addition was complete the mixture was stirred for a further 2 hours at the ambient temperature and for 3 hours at the reflux temperature. Water at 0 C. was added to the mixture, which was then acidified with dilute hydrochloric acid and extracted with diethyl ether (2*80 cm3). The extracts were combined, washed with water, dried over anhydrous magnesium sulphate and concentrated by evaporation of the solvent under reduced pressure. The residual oil (4.6 g) was shown by gas liquid chromatographic examination of a sample to consist of ca. 70% by weight of unreacted starting material and ca. 30% by weight of product. The oil was subjected to vigorous purification by column and thin-layer chromatography using a silica gel support and eluding with a mixture of diethyl ether and hexane (3:7 by volume), to obtain 2-methyl-3,4,5,6-tetrafluorobenzyl alcohol as a colourless oil. 1 H nmr (CDCl3) delta: 1.86 (broad s,1H); 2.35 (q,3H); 4.74 (d,2H). 19 F nmr (CDCl3) delta: -142.3 (dd, J=12.6, 21Hz); -145.9 (dd, J=12.6, 21Hz); -157.25 (t,J=21Hz); -160.5 (t,J=21Hz);

With the rapid development of chemical substances, we look forward to future research findings about 440-60-8.

Reference:
Patent; Imperial Chemical Industries PLC; US4714790; (1987); A;,
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1462-03-9 ,Some common heterocyclic compound, 1462-03-9, molecular formula is C6H12O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Preparation 8; 1-Methvl-cvclopentvlamine hvdrochloride; A solution of 2.00 g (20 mmol) of 1-methylcyclopentanol in 25 mL of benzene was treated with 3.18 mL (24 mmol) of azidotrimethylsilane and 3.04 mL (24 mmol) of boron trifluoride etherate as described by Zwierzak, et al., Tetrahedron Letters, 1987, 6513. After about 24 hrs, the solution was poured into 50 mL of 1 M sodium bicarbonate solution and stirred for 30 minutes, adding solid sodium bicarbonate as needed to maintain pH > 7. The benzene layer was separated and dried over anhydrous calcium chloride. The benzene solution was diluted with 25 mL of methanol hydrogenated over 0.45 g of 10% Pd/C catalyst for 90 minutes at 45 psi and 20 C. The reaction mixture was then filtered through diatomaceous earth, 1.7 mL of 12 M hydrochloric acid was added to the filtrate, and the solvent was evaporated to provide 1.92 g (71%) of the title compound as a white solid. NMR (D2O) : 1.59 (m, 8 H); 1.22 (s, 3 H). APCI MS: 100 (MH+). mp: 261-262 C.

According to the analysis of related databases, 1462-03-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PFIZER PRODUCTS INC.; WO2005/95339; (2005); A1;,
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627-18-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 627-18-9, name is 3-Bromopropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

Take a 500 mL three-necked flask dried in an oven, equipped with a mechanical stirrer and a thermometer. Add 98% sulfuric acid (50.0 g, 0.5 mol), dichloromethane 60 mL, and cool to -5 to 5 C in an ice salt bath. Fuming nitric acid (33.5g, 0.5mol) was slowly added. Then, 3-bromo-1-propanol (46 g, 0.33 mol) was added dropwise to the mixture, and the reaction medium was stirred at -5 to 5 C for 4 to 5 hours. The mixture was poured into cold water (350 g) maintaining the temperature between -5 and 5 C. After pouring, the organic phase was taken, 80 mL of dichloromethane was added to the aqueous phase, the organic phase was combined, the combined organic phases were washed with water, adjusted to pH = 6-7 by adding 8% sodium hydroxide, washed with brine, organic phase Dry with magnesium sulfate. Dichloromethane was evaporated under reduced pressure to give 3-bromopropyl nitrate (yield compound of formula M) (53.5 g, 88.1%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 627-18-9, 3-Bromopropan-1-ol.

Reference:
Patent; Chongqing Weipeng Pharmaceutical Co., Ltd.; Li Nenggang; Liu Zeyan; Lin Song; Chen Xiaopeng; Zhou Xingguo; Yao Hequan; (18 pag.)CN108892624; (2018); A;,
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