Reference of 7073-69-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.7073-69-0, name is 2-(2-Bromophenyl)propan-2-ol, molecular formula is C9H11BrO, molecular weight is 215.087, as common compound, the synthetic route is as follows.
In a 250 mL three-necked flask, 0.03 mol of dibenzofuran-3-amine, 0.04 mol of 2-(2-bromophenyl)propan-2-ol, and 150 mL of toluene were stirred and mixed under a nitrogen atmosphere.Then adding 0.05 mol of sodium t-butoxide, 0.0015 mol of Pd2 (dba) 3, 0.0015 mol of tri-tert-butylphosphine, heating to 115 C, refluxing reaction for 24 hours;Naturally cooled to room temperature, filtered, and the filtrate was subjected to vacuum distillation (-0.09 MPa, 85 C).Passing through a neutral silica gel column to give 2-(2-(dibenzofuran-3-ylamino)phenyl)propan-2-ol;
The chemical industry reduces the impact on the environment during synthesis 7073-69-0, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Miao Kangjian; Zhang Zhaochao; Zhang Xiaoqing; Li Chong; (37 pag.)CN108203427; (2018); A;,
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