Adding a certain compound to certain chemical reactions, such as: 41175-50-2, 1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quinolin-8-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks
[00100] In a 50 mL round-bottom flask equipped with stir bar, 5-carboxyphthalaldehydic acid (116 mg, 0.60 mmol), 2,3,6,7-tetrahydro-lH,5H-pyrido[3,2,l-ij]quinolin-8-ol (238 mg, 1.25 mmol) and trifluoroethanol (25 mL). Oxygen was allowed to bubble through the solution for 5 minutes. The resulting dark brown solution was gently warmed up under oxygen atmosphere to 75C and stirred vigorously for 21 hours. The solvent was concentrated in vacuo, and dark blue residue was purified by silica gel chromatography (0? 60% MeOH/DCM) to provide 279 mg (87% yield) of 5-ROX as a dark blue solid. l NMR (300 MHz, CD2Cl2-TFIP-c delta 8.77 (d, J= 1.6 Hz, 1H), 8.28 (dd, J= 7.9, 1.8 Hz, 1H), 7.40 (d, J = 8.0 Hz, 1H), 6.66 (s, 2H), 3.55 – 3.42 (m, 8H), 3.11 (t, J= 6.3 Hz, 4H), 2.70 (t, J = 6.0 Hz, 4H), 2.19 – 2.09 (m, 4H), 2.03 – 1.94 (m, 4H); 1 C NMR (75 MHz, CD2Cl2-TFIP-c delta 174.0, 171.2, 155.9, 153.4, 152.6, 139.4, 135.90, 134.1, 133.4, 132.9, 132.1, 126.8, 125.5, 113.7, 106.6, 51.9, 51.4, 28.2, 21.4, 20.8, 20.5; HRMS (ESI+) calc’d for C33H3iN205+ [M+H]+ 535.2227 found 535.2228.
The synthetic route of 41175-50-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PROMEGA CORPORATION; DWIGHT, Stephen, J.; LEVIN, Sergiy; (38 pag.)WO2017/59308; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts