With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.33036-62-3, name is 4-Bromo-1-butanol, molecular formula is C4H9BrO, molecular weight is 153.0177, as common compound, the synthetic route is as follows.Recommanded Product: 4-Bromo-1-butanol
PREPARATION 9 1-Tetrahydropyranyloxy-4-bromobutane (Formula XIII: A is trimethylene). Concentrated hydrobromic acid (75 drops of 48%) is added with stirring to a mixture of 4-bromobutanol (150 ml.) and dihydropyran (300 ml.) at 0. This mixture is stirred and allowed to warm slowly to 25 C. during 15 hours. Evaporation under reduced pressure gives a residue which is divided into two equal parts, each part being chromatographed on 1.5 kg. of silica gel, each column being eluted with 7.5 l. of 5% ethyl acetate in Skellysolve B, and then with 4 l. of 7.5% ethyl acetate in Skellysolve B, collecting 500 ml. fractions. Fractions 5-11 from each column are evaporated to give a total of 240 g. of 1-tetrahydropyranyloxy-4-bromobutane.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,33036-62-3, 4-Bromo-1-butanol, and friends who are interested can also refer to it.
Reference:
Patent; The Upjohn Company; US4008263; (1977); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts