Adding a certain compound to certain chemical reactions, such as: 111-90-0, Diethylene Glycol Monoethyl Ether, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 111-90-0, blongs to alcohols-buliding-blocks compound. Recommanded Product: Diethylene Glycol Monoethyl Ether
Example 89b; Sodium hydride (60% in oil, 40 mg) was added to a mixture of 2-chloro-4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidine-5-carbaldehyde (150 mg) obtained in Example 89a), 2-(2-ethoxyethoxy)ethanol (134 mg) and N,N-dimethylformamide (3 ml), and the resulting mixture was stirred for one hour at room temperature. Furthermore, 2-(2-ethoxyethoxy)ethanol (134 mg) and sodium hydride (60% in oil, 40 mg) were sequentially added thereto, and the resulting mixture was stirred for 15 hours at 100 C. The reaction mixture was returned to room temperature, and then the solvent was distilled off under reduced pressure. The residue was diluted with ethyl acetate, and the dilution was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The resulting residue was purified by chromatography, and was recrystallized from a mixed solvent of ethyl acetate/hexane. Thus, the title compound (85 mg) was obtained as a white powder.1H NMR (300 MHz, CHLOROFORM-d) delta ppm 1.18 (3H, t, J=8.2 Hz), 3.36-3.52 (6H, m), 3.68 (2H, dd, J=5.7, 3.8 Hz), 4.40 (2H, q, J=8.2 Hz), 4.45-4.52 (2H, m), 6.33-6.41 (1H, m), 7.04(2H, d, J=9.1 Hz), 7.17-7.25 (3H, m), 9.51 (1H, br. s.).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,111-90-0, its application will become more common.
Reference:
Patent; Suzuki, Hideo; Fujimoto, Takuya; Yamamoto, Takeshi; US2010/190747; (2010); A1;,
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