Reference of 629-30-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.629-30-1, name is 1,7-Heptanediol, molecular formula is C7H16O2, molecular weight is 132.2, as common compound, the synthetic route is as follows.
7- bromoheptane-l-ol1 (2): Heptane- 1,7-diol (36.0 g, 272 mmol; Alfa Aesar) and aq. 48% HBr (38 mL, 0.9 equiv.) were heated under reflux in benzene (400 mL) with water removal using a Dean-Stark apparatus. After 16 h, all volatiles were removed in vacuo and the residue was purified by Si02 column chromatography using a gradient of 10-30% EtOAc/hexanes as eluent to give 7-bromoheptan-l-ol (26.22 g, 62%) as a colorless oil. TLC: 50% EtOAc/hexanes, Rf ~ 0.40; NMR (400 MHz, CDC13) delta 3.61 (t, 2H, J = 7.1 Hz), 3.39 (t, 2H, J= 6.8 Hz), 1.80- 1.88 (m, 2H), 1.52-1.58 (m, 2H), 1.30-1.46 (m, 6H).
The chemical industry reduces the impact on the environment during synthesis 629-30-1, I believe this compound will play a more active role in future production and life.
Reference:
Patent; MCW RESEARCH FOUNDATION, INC.; IMIG, John, David; CAMPBELL, William, B.; FALCK, John, Russell; WO2012/138706; (2012); A1;,
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