With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.15484-46-5, name is Methyl 2-(hydroxymethyl)acrylate, molecular formula is C5H8O3, molecular weight is 116.12, as common compound, the synthetic route is as follows.Product Details of 15484-46-5
MgI2 (683 mg, 2.45 mmol) was added to anhydrous CH2Cl2 (6 mL), and the mixture was stirred at normal temperature for 45 min. The mixture was cooled to -78 C., and then methyl 2-(hydroxymethyl)acrylate dissolved in anhydrous CH2Cl2 (8 mL) was added thereto. The mixture was further stirred at -78 C. for 30 min, and then isopropyl iodide (417 mg, 24.5 mmol), Bu3SnH (2.57 mg, 8.84 mmol) and Et3B (8.84 mL, 8.84 mmol, 1.0 M/hexane solution) in sequence were slowly added thereto. Immediately after all were added thereto, air (20 mL) was slowly added thereto through a syringe. After the mixture was stirred for 2 hr and 30 min, the reactant was diluted in diethyl ether (120 mL). Silica gel (10 g) was added thereto, and then the resulting mixture was evaporated under reduced pressure. The powder obtained was washed with hexane (500 mL) and extracted with diethyl ether (300 mL), evaporation was performed under reduced pressure, and then column chromatography was used to obtain 150 mg (yield 78%) of the title compound. 1H NMR (300 MHz, CDCl3) d 0.87 (d, J=6.0 Hz, 3H), 0.88 (d, J=5.4 Hz, 3H), 1.32-1.38 (m, 1H), 1.41-1.76 (m, 2H), 2.34 (s, 1H), 2.45-2.86 (m, 1H), 3.68-3.70 (m, 2H), 3.68 (s, 3H); 13C NMR (75 MHz, CDCl3) d 22.16, 22.43, 25.78, 37.86, 45.45, 51.89, 63.38, 162.18, 176.11.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,15484-46-5, Methyl 2-(hydroxymethyl)acrylate, and friends who are interested can also refer to it.
Reference:
Patent; Korea Institute of Science and Technology; MIN, Sun Joon; Cho, Yong Seo; Lee, Jae Kyun; Pae, Ae Nim; Son, Young Wook; US2013/197227; (2013); A1;,
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