In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10602-04-7, name is (4-Ethynylphenyl)methanol, the common compound, a new synthetic route is introduced below. Computed Properties of C9H8O
Example 13; {4-[2,6-bis-(4-hydroxymethyl-phenylethynyl)-pyridin-4-ylsulfanyl]-2-methyl-phenoxy}-acetic acid; General procedure (A); Step B:; 7-(2,6-Dibromo-pyridin-4-ylsulfanyl)-2-methyl-phenoxy}-acetic acid methyl ester (0.3 g; 0.67 mmol, prepared as described in example 6), cupper iodide (3.8 mg; 0.02 mmol), 4- ethynylbenzylalcohol (266 mg; 2,01 mmol) and bis (triphenylphosphine) (II) chloride (18.8 mg; 0,027 mmol) were added to a dry reaction flask under an atmosphere of nitrogen. Triethylamine (2 ml) and DMF (2 ml) was added and the reaction mixture was reacted at 70 ¡ãC for 10 min in a microwave oven. The reaction mixture was purified by preparative HPLC (method B) to give {4-[2,6-bis-(4-hydroxymethyl-phenylethynyl)-pyridin-4-ylsulfanyl]-2-methyl- phenoxy}-acetic acid methyl ester. Yied: 260 mg; 70 percent. LC-MS (system 1): Rt: 3.02 min.; Mw: 576.4.
The synthetic route of 10602-04-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVO NORDISK A/S; WO2005/105726; (2005); A1;,
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