Application of 10602-04-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10602-04-7, name is (4-Ethynylphenyl)methanol, molecular formula is C9H8O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: The corresponding alkyne (1.1e2.2 mmol) was added to a solutionof azide ester (¡À)-2 (1 mmol), Na ascorbate (0.5 mmol) andCuSO4.5H2O (0.05 mmol) in t-BuOH (1 mL)/H2O (1 mL) underargon. The reaction mixture was transferred to the microwavesystem and was irradiated for 10e160 min between 70 and 90 C,using an irradiation power of 100 W. Removal of solvents underreduced pressure afforded a solid residue, which was purified byrecrystallization or by column chromatography on silica gel
According to the analysis of related databases, 10602-04-7, the application of this compound in the production field has become more and more popular.
Reference:
Article; Ferreira Da Costa, Joana; Garcia-Mera, Xerardo; Caamano, Olga; Brea, Jose Manuel; Loza, Maria Isabel; European Journal of Medicinal Chemistry; vol. 98; (2015); p. 212 – 220;,
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