Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 16545-68-9, name is Cyclopropanol. A new synthetic method of this compound is introduced below., Recommanded Product: 16545-68-9
Cyclopropanol (340mg, 5.85mmol) dissolved in tetrahydrofuran (10 mL), compound a87 (1,00g, 5.32mmol), potassium carbonate (1.62g, 11.7mmol)And 18-crown ether -6 (4.22g, 16.0mmol) was added, and the mixture was stirred for 3 h at 60C . Water and 1.0mol / L hydrochloric acid solution was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The resulting residue was purified by silica gel chromatography – (hexane-ethyl acetate) to give the compound a88 (254mg, 21% yield).
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Reference:
Patent; Shionogi & Co., Ltd.; Oyabu, kyoju; Kurahashi, Kana; Nishiura, Yuji; Kato, Manabu; Miyazaki, Keisuke; Wada, Toshihiro; Sasaki, Giichi; Iwatsu, Masafumi; (167 pag.)JP2016/79168; (2016); A;,
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