Application of 2002-24-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2002-24-6, name is 2-Aminoethanol hydrochloride, molecular formula is C2H8ClNO, molecular weight is 97.544, as common compound, the synthetic route is as follows.
9-(2′-hydroxyethylamino)-7-methoxy-4-methyl-1-nitroacridine 7-Methoxy-4-methyl-1 -nitro-9-phenoxyacridine (0.72 g) is dissolved in phenol (20 g). Ethanolamine hydrochloride (0.2 g) is added and the mixture is heated at 80 C. for 1.5 hour. The reaction mixture is cooled to room temperature, diluted with dry ether, slowly poured into dry ether (300 ml) and acidified with ethereal solution of hydrogen chloride. The resulting precipitate is filtered off, washed twice with ether and crystallized from absolute methanol to give 9-(2′-hydroxyethylamino)-7-methoxy-4-methyl-1-nitroacridine monohydrochloride as orange crystals (0.6 g, 86%), m.p. 200 C. (decomp.) 1H NMR (d6DMSO): delta2.60 (s, 3H, CH3), 3.50 (s, 4H, H-1′, H-2′), 4.00 (s, 3H, OCH3), 7.66 (dd, 1 H, J1=9.3 Hz, J2=2.5 Hz, H-6), 7.85 (d, 1 H, J =8.2 Hz, H-3), 8.02 (s, 1 H, H-8), 8.15 (d, 1 H, J =7.8 Hz, H-2), 8.22 (d, 1 H, J=7.8 Hz, H-5).
Statistics shows that 2002-24-6 is playing an increasingly important role. we look forward to future research findings about 2-Aminoethanol hydrochloride.
Reference:
Patent; Konopa, Jerzy Kazimierz; Wysocka-Skrzela, Barbara; Tiwari, Raj; US2002/99211; (2002); A1;,
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