In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 457889-46-2, name is (4′-(Trifluoromethyl)-[1,1′-biphenyl]-4-yl)methanol, the common compound, a new synthetic route is introduced below. Application In Synthesis of (4′-(Trifluoromethyl)-[1,1′-biphenyl]-4-yl)methanol
Example 11A 4-Chloromethyl-4′-trifluoromethylbiphenyl A solution of 5.00 g (19.8 mmol) of (4′-trifluoromethylbiphenyl-4-yl)methanol in 40 ml of chloroform is mixed with 2.89 ml (39.7 mmol) of thionyl chloride dissolved in 10 ml of chloroform, and the mixture is stirred at room temperature over 12 hours. After reaction is complete, the reaction mixture is concentrated to dryness, and the residue is taken up ethyl acetate and washed with saturated sodium carbonate solution. The organic phase is subsequently separated off, dried over sodium sulfate and concentrated after filtration. The resulting crude product is purified by flash chromatography on silica gel 60 (mobile phase: cyclohexane/ethyl acetate 9:1). 5.26 g (19.4 mmol, 98% of theory) of the title compound are obtained. 1H-NMR (300 MHz, DMSO-d6, delta/ppm): 4.83 (s, 2H), 7.58 (d, 2H), 7.78 (d, 2H), 7.91 (d, 2H), 7.82 (d, 2H). MS (E1): 270 (M+).
The synthetic route of 457889-46-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Bartel, Stephan; Hahn, Michael; Moradi, Wahed Ahmed; Becker, Eva-Maria; Roelle, Thomas; Stasch, Johannes-Peter; Schlemmer, Karl-Heinz; Wunder, Frank; Knorr, Andreas; US2009/291993; (2009); A1;,
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