With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.63012-03-3, name is (3-Chlorophenyl)(phenyl)methanol, molecular formula is C13H11ClO, molecular weight is 218.68, as common compound, the synthetic route is as follows.category: alcohols-buliding-blocks
General procedure: To a solution of thiol 1 (0.5 mmol) in anhyd CH2Cl2 (2 mL) was added diaryl carbinol 2 (0.6 mmol) and BF3*OEt2 (5 mol% solution in CH2Cl2; 1 mL). The reaction mixture was stirred vigorously for <1 min. After completion of the reaction as checked by TLC, the solvent was removed under reduced pressure, and the residue was subjected to silica gel column chromatography by using 5-10% EtOAc in hexanes to afford the desired symmetrical and unsymmetrical diarylmethyl thioether in good to quantitative yield.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,63012-03-3, (3-Chlorophenyl)(phenyl)methanol, and friends who are interested can also refer to it.
Reference:
Article; Singh, Pallavi; Peddinti, Rama Krishna; Synthesis; vol. 49; 16; (2017); p. 3633 – 3642;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts