Adding a certain compound to certain chemical reactions, such as: 18776-12-0, 3-Chloro-1-phenylpropan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C9H11ClO, blongs to alcohols-buliding-blocks compound. Computed Properties of C9H11ClO
A mixture of 3-chloro-1 -phenylpropan-1 -ol (p281 , 7.50 g, 43.95 mmol) and 48% aqueous hydrobromic acid (98 mL) was stirred at RT for 3 hrs, then cautiously poured into a mixture of potassium carbonate (27 g) and 180 g of ice. Potassium carbonate was cautiously added up to neutral pH. The resulting mixture was extracted twice with ether, the organic phase was dried and the solvent removed under vacuum. The crude material was purified by FC on silica gel (eluting with Cy) affording (1-bromo-3-chloropropyl)benzene (p282, 7.49 g, y= 73%) as colourless oil. NMR: 1 H NMR (CDC ) delta: 7.32-7.50 (m, 5H), 5.24 (m, 1 H), 3.75 (m, 1 H), 3.61 (m, 1 H), 2.67- 2.80 (m, 1 H), 2.45-2.58 (m, 1 H)
The synthetic route of 18776-12-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; INDIVIOR UK LIMITED; CREMONESI, Susanna; MICHELI, Fabrizio; SEMERARO, Teresa; TARSI, Luca; (364 pag.)WO2016/67043; (2016); A1;,
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