Application of 770-71-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.770-71-8, name is Adamantan-1-ylmethanol, molecular formula is C11H18O, molecular weight is 166.26, as common compound, the synthetic route is as follows.
General procedure: To the solution of starting alcohol 2 (6 mmol) in dichloromethane(8 mL) was added Et3N (0.84 mL, 606 mg, 6 mmol) inatmosphere of Ar. The mixture was cooled to 0 to 5 C and theacryloyl chloride (0.49 mL, 543 mg, 6 mmol) in dichloromethane(2 mL) was added dropwise. The resulting mixture was stirred atthis temperature for 3 h and then at room temperature for 24 h.The reaction mixture was poured into water (15 mL) and extractedwith dichloromethane (4 20 mL). The combined organic layer waswashed with brine solution (3 20 mL) and was dried over anhydrousMg2SO4. The solvent was evaporated in vacuo; the residuewas purified by preparative column chromatography on silica gel.
Statistics shows that 770-71-8 is playing an increasingly important role. we look forward to future research findings about Adamantan-1-ylmethanol.
Reference:
Article; Averina, Elena B.; Vasilenko, Dmitry A.; Gracheva, Yulia A.; Grishin, Yuri K.; Radchenko, Eugene V.; Burmistrov, Vladimir V.; Butov, Gennady M.; Neganova, Margarita E.; Serkova, Tatyana P.; Redkozubova, Olga M.; Shevtsova, Elena F.; Milaeva, Elena R.; Kuznetsova, Tamara S.; Zefirov, Nikolay S.; Bioorganic and Medicinal Chemistry; vol. 24; 4; (2016); p. 712 – 720;,
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