149104-89-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 149104-89-2, name is (4-Bromo-3-methylphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.
[00157] Step 2: A solution of (4-bromo-3-methylphenyl)methanol (5.0 g, 24.87 mmol) and imidazole (5.1 g, 74.61 mmol) in THF (50 mL) was cooled to 0 ¡ãC and treated with chloro(triisopropyl)silane (7. 2 g, 7.9 mL, 37.30 mmol), then allowed to warm to room temperature and stirred for 16 h. The reaction mixture was diluted with water and DCM. The organic layer was washed with brine, dried over Na2S04, filtered, and concentrated in vacuo to yield (4-bromo-3-methylbenzyloxy)triisopropylsilane as a colorless oil, (8.8 g, 97percent yield). XH NMR (400 MHz, CDC13) delta 7.47 (d, J= 8.2 Hz, 1H), 7.21 (s, 1H), 7.04 (d, J= 8.1 Hz, 1H), 4.75 (s, 2H), 2.39 (s, 3H), 1.22 – 1.14 (m, 3H), 1.09 (d, J= 6.5 Hz, 18H).
Statistics shows that 149104-89-2 is playing an increasingly important role. we look forward to future research findings about (4-Bromo-3-methylphenyl)methanol.
Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; CHARRIER, Jean-Damien; BINCH, Haley, Marie; HURLEY, Dennis, James; CLEVELAND, Thomas; JOSHI, Pramod; FANNING, Lev Tyler, Dewey; PINDER, Joanne; O’DONNELL, Michael; VIRANI, Anisa, Nizarali; KNEGTEL, Ronald, Marcellus Alphonsus; DURRANT, Steven, John; YOUNG, Stephen, Clinton; PIERRE-HENRI; KAY, David; REAPER, Philip, Michael; WO2011/143426; (2011); A1;,
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