64372-62-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 64372-62-9, name is 2-Chloro-5-(trifluoromethyl)benzyl alcohol. A new synthetic method of this compound is introduced below.
Step 5a. Palladium Catalyzed Suzuki Coupling-AllylPdCl Dimer Catalyst In a 250 ml flask equipped with a reflux condenser was placed 2-chloro-5-(trifluoromethyl)benzyl alcohol (10 g; 47.5 mmol), 4-fluoro-5-isopropyl-2-methoxyphenylboronic acid (10.81 g; 95 wt % purity, 48.4 mmol), acetonitrile (80 ml) and 3 M K2CO3 (42.7 ml, 128 mmol). The resulting biphasic solution was sparged with nitrogen for several minutes. [AllylPdCl]2 (0.043 g, 0.119 mmol) and PCy3.HBF4 (0.087 g, 0.237 mmol) were added under nitrogen flow, and the reaction mixture was warmed to 70 C. until HPLC showed the reaction was complete. [0046] The reaction mixture was then cooled to room temperature and the phases were separated. The organic layer was washed with 10% NaCl solution (50 ml). After phase separation, Darco KB-G activated carbon (2.0 g) was added to the organic layer, and the mixture was stirred for 1 hr at room temperature. The mixture was then filtered through a pad of Solka-Floc. The filtrate was assayed and was found to contain 15.5 g of product (95% yield). The filtrate was azeotropically dried with acetonitrile and concentrated to an oil under vacuum. The crude product was used in the next step without further treatment.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,64372-62-9, 2-Chloro-5-(trifluoromethyl)benzyl alcohol, and friends who are interested can also refer to it.
Reference:
Patent; Chung, Cheol K.; Humphey, Guy R.; Maligres, Peter E.; Wright, Timothy J.; US2014/303380; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts