Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 558-42-9, name is 1-Chloro-2-methyl-2-propanol. This compound has unique chemical properties. The synthetic route is as follows. 558-42-9
6-Methoxy-l’- (2-phenoxyethyl)-2, 3,4, 9-tetrahydrospiro[beta-carboline-1, 3′-pyrrolidine] (EXAMPLE 10,66 mg, 0.2 mmol, K2CO3 (48 mg, 0.3 mmol), 1-chloro-2-methylpropan-2- ol (28 mg, 0.3 mmol) and acetonitrile (2 mL) were stirred at75 C for 16h. MoreK2CO3 (48 mg, 0.3 mmol), 1-chloro-2-methylpropan-2-ol (28 mg, 0.3 mmol) were added to the reaction and1-chloro-2-methylpropan-2-ol (28 mg, 0.3 mmol) was added again after 24h and 48h. After another 72h, the mixture was filtered and the solvent was removed. The product was purified by preparative HPLC using acetonitrile-water gradients containing 0.1percent trifluoroacetic acid. Yield: 6.96 mg (8percent).HPLC 98percent, RT : 2.099 (10-97percent MeCN over 3 min). ‘H NMR (270 MHz, Methanol-d3)8 ppm 1.26 (s, 3 H) 1.35 (s, 3 H) 2.46-2. 53 (m,1 H) 2.84-3. 04 (m,1 H) 3.04-3. 14 (m, 2 H) 3. 47-3. 66 (m,6 H) 3.81 (s,3 H) 3.84 (dd,J=6. 68,3. 22 Hz, 2 H) 4.18-4. 29 (m,1 H) 4.32-4. 35 (m, 2 H) 6.81(dd,J=8. 91,2. 47 Hz, 1 H) 6.95-7. 02 (m, 4 H) 7.23-7. 33 (m,3 H).
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 558-42-9, 1-Chloro-2-methyl-2-propanol.
Reference:
Patent; BIOVITRUM AB; WO2005/48916; (2005); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts