Adding a certain compound to certain chemical reactions, such as: 100-37-8, 2-(Diethylamino)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 100-37-8, blongs to alcohols-buliding-blocks compound. 100-37-8
0 C, under Ar protection,To NaH (60%, 1.1g, 27.01mmol, 2.5eq)Compound 2 (1.52 g, 12.97 mmol, 1.2 eq) was added dropwise to a solution of THF (15 mL)Of THF (5 mL).Stir at 0 C for 15 min.Compound 1 (2.0 g, 10.80 mmol, 1.0 eq) was added.Stir overnight at room temperature. The reaction was quenched with saturated NH4Cl.The reaction solution was concentrated under reduced pressure, diluted with water (40 mL), washed with PE: EtOAc = 10: 1 (40 mL), and adjusted to pH = 4 with 5M aq.Filtration gave compound 3 (3.0 g, 82%) as a white solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,100-37-8, its application will become more common.
Reference:
Patent; Longtaishen Pharmaceutical (Nanjing) Co., Ltd.; Yang Lei; (55 pag.)CN110698460; (2020); A;,
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