1462-03-9 ,Some common heterocyclic compound, 1462-03-9, molecular formula is C6H12O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Preparation 8; 1-Methvl-cvclopentvlamine hvdrochloride; A solution of 2.00 g (20 mmol) of 1-methylcyclopentanol in 25 mL of benzene was treated with 3.18 mL (24 mmol) of azidotrimethylsilane and 3.04 mL (24 mmol) of boron trifluoride etherate as described by Zwierzak, et al., Tetrahedron Letters, 1987, 6513. After about 24 hrs, the solution was poured into 50 mL of 1 M sodium bicarbonate solution and stirred for 30 minutes, adding solid sodium bicarbonate as needed to maintain pH > 7. The benzene layer was separated and dried over anhydrous calcium chloride. The benzene solution was diluted with 25 mL of methanol hydrogenated over 0.45 g of 10% Pd/C catalyst for 90 minutes at 45 psi and 20 C. The reaction mixture was then filtered through diatomaceous earth, 1.7 mL of 12 M hydrochloric acid was added to the filtrate, and the solvent was evaporated to provide 1.92 g (71%) of the title compound as a white solid. NMR (D2O) : 1.59 (m, 8 H); 1.22 (s, 3 H). APCI MS: 100 (MH+). mp: 261-262 C.
According to the analysis of related databases, 1462-03-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PFIZER PRODUCTS INC.; WO2005/95339; (2005); A1;,
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