6338-55-2, Adding a certain compound to certain chemical reactions, such as: 6338-55-2, 2-(2-(2-Aminoethoxy)ethoxy)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 6338-55-2, blongs to alcohols-buliding-blocks compound.
2-(2-(2-aminoethoxy)ethoxy)ethanol (0.6 g, 4.062 mmol) was dissolved in acetonitrile (25 ml). The solution was cooled to 0C and Et3N (1.13 ml, 8.12 mmol, 2 eq.) was added followed by Boc2O (0.268 g, 1.23 mmol). The reaction was followed by TLC and stirred overnight at room temperature. Water (15 ml) was added and the solution was extracted with EtOAc (3×30 ml), brine was used to help separating the two layers (5 ml) and also (30 ml) for washing. The combined organic layers were dried over Na2SO4, filtered and concentrated under reduced pressure. The crude product was purified by flash chromatography on silica gel (CH2Cl2/MeOH, 96:4) to give the title compound as a yellow oil (0.670 g, 66 % yield)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6338-55-2, its application will become more common.
Reference:
Article; Simonin, Jonathan; Vernekar, Sanjeev Kumar V.; Thompson, Andrew J.; Hothersall, J. Daniel; Connolly, Christopher N.; Lummis, Sarah C.R.; Lochner, Martin; Bioorganic and Medicinal Chemistry Letters; vol. 22; 2; (2012); p. 1151 – 1155;,
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