Introduction of a new synthetic route about 575-03-1

The chemical industry reduces the impact on the environment during synthesis 575-03-1, I believe this compound will play a more active role in future production and life.

In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 575-03-1 as follows., 575-03-1

General procedure: The corresponding coumarin derivatives (4.21mmol) 5a-k and potassium carbonate (0.872 g, 6.31 mmol) were suspended in dry acetone, and then the corresponding dibromoalkyl derivative (84.12 mmol) was added. The mixture was refluxed for 6 h. After cooling to room temperature, the solid was filtered and washed with acetone. The filtrate was concentrated under reduced pressure and purified by column chromatography using petroleum ether/ethy actate (5 : 1 to 8:1) as eluent to get the intermediates of 6a-n

The chemical industry reduces the impact on the environment during synthesis 575-03-1, I believe this compound will play a more active role in future production and life.

Reference:
Article; He, Qi; Liu, Jing; Lan, Jin-Shuai; Ding, Jiaoli; Sun, Yongbing; Fang, Yuanying; Jiang, Neng; Yang, Zunhua; Sun, Liyuan; Jin, Yi; Xie, Sai-Sai; Bioorganic Chemistry; vol. 81; (2018); p. 512 – 528;,
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