The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2854-16-2, name is 1-Amino-2-methylpropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. 2854-16-2
Example 15. 6-Bromo-8-cvclopentyl-2-(2-hvdroxy-2-methylpropylamino)-4-methylpyridof2.3-ty|pyrimidin- 7(betaH)-one; To a solution of 6-bromo-8-cyclopentyl-4-methyl-2-(methylsulfinyl)pyrido[2,3-cdpyrimidin-7(8/-/)- one (600 mg, 1.62 mmol) and 1-amino-2-methylpropan-2-ol (294 mg, 2.34 mmol) in dioxane (6 ml_) was added triethylamine (1.2 ml_, 8.6 mmol). The mixture was then heated at 110 0C in a sealed tube for 1 h. The solution was poured into brine and extracted with ethyl acetate. The organic was dried (anhydrous sodium sulfate), filtered and concentrated to dryness. The crude product was purified by silica gel flash chromatography to give the title compound as a solid (565 mg, 88percent).LRMS: 395, 397 (M+H)+.1H NMR (CDCI3, 400 MHz): 8.07 (1 H, s), 5.91-6.13 (1 H, m), 5.46-5.90 (1 H, m), 3.52 (2H, d, J = 6.32 Hz), 2.54 (3H, s), 2.17-2.43 (2H, m), 1.95-2.16 (2H, m), 1.76-1.95 (2H, m), 1.56-1.74 (3H, m), 1.30 (6H, s).
Statistics shows that 2854-16-2 is playing an increasingly important role. we look forward to future research findings about 1-Amino-2-methylpropan-2-ol.
Reference:
Patent; PFIZER PRODUCTS INC.; WO2008/32162; (2008); A1;,
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