The common heterocyclic compound, 616-29-5, name is 1,3-Diaminopropan-2-ol, molecular formula is C3H10N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route. 616-29-5
Example 1 11- {[tert-Butyl (dimethyl) silyl] oxy}-9- (methylsulfonyl)-9, 10,11, 12-tetrahydro-8H [1, 4] diazepino [1′, 2′ : 1, 2] imidazo [4,5-c] quinolin-6-amine Part A Under a nitrogen atmosphere, a solution of di-tert-butyl dicarbonate (145. 35 g, 665.98 mmol) in 1,4-dioxane (400 mL) was added dropwise with stirring to a solution of 2-hydroxy-1, 3-diaminopropane (300.00 g, 332.85 mmol) in methanol (500 mL) over a period of six hours. The reaction was stirred overnight at ambient temperature and then concentrated under reduced pressure. The residue was dissolved in 10% citric acid in water, and additional citric acid was added to adjust the solution to pH 4. The resulting solution (1-1.5 L) was washed with dichloromethane (3 x 500 mL) and then adjusted to pH 12 with the addition of 50% aqueous sodium hydroxide. The basic solution was extracted with chloroform (7 x 500 mL), and the combined extracts were concentrated under reduced pressure and dried overnight under high vacuum to provide 108. 19 g of tert-butyl 3-amino-2-hydroxypropylcarbamate as a white solid.
The synthetic route of 616-29-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; 3M INNOVATIVE PROPERTIES COMPANY; WO2005/66172; (2005); A1;,
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