A new synthetic route of 2854-16-2

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2854-16-2.

2854-16-2, Adding some certain compound to certain chemical reactions, such as: 2854-16-2, name is 1-Amino-2-methylpropan-2-ol,molecular formula is C4H11NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2854-16-2.

Preparation of compound 2-4 To a solution of 2-3 (10 g, 41 mmol) and TEA (5 g, 49 mmol) in DCM was added 2-a (3 g, 34 mmol) dropwise. The mixture was stirred for 12 hrs at 40¡ãC. The solution was cooled down to r.t., and washed with brine, dried over anhydrous Na2SO4 and filtered. The filtration was concentrated and crude product was obtained. Further purification by silica gel column chromatography (PE: EA=1: 1) afforded 6.0 g desiredproduct, yield 50percent.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2854-16-2.

Reference:
Patent; ASCEND BIOPHARMACEUTICALS PTY LTD; PIETERSZ, Geoffrey, Alan; WO2013/67597; (2013); A1;,
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