Month: November 2020

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 612-16-8, name is (2-Methoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. 612-16-8

1.02 g (7.38 mmol, 1.0 eq) compound 13c was dissolved in 40 ml CH2Cl2, then 0.84 ml (8.90 mmol, 1.2 eq) PBr3 was added under the condition of ice water bath. After reacting for an hour, a little saturated sodium bicarbonate solution was added to wash the organic phase followed by twice wash with saturated sodium chloride solution, then dried over anhydrous sodium sulfate and desolventizing to gain 1.15 g reddish colored oily material (Compound 8-2c), yield 77.5%. The crude product was used without purification in the next step directly. Compound 8-2a, 8-2b, and 8-2d can be obtained in the same way from compound 13a, 13b, and 13d.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 612-16-8, (2-Methoxyphenyl)methanol.

Reference:
Patent; Fudan University; YE, Deyong; LI, Yali; ZHOU, Lu; WANG, Penghui; CHU, Yong; GONG, Haojun; HUANG, Qi; CHEN, Yan; ZHANG, Zhikuan; (40 pag.)EP3196191; (2017); A1;,
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Adding some certain compound to certain chemical reactions, such as: 100-37-8, name is 2-(Diethylamino)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 100-37-8. 100-37-8

EXAMPLE 24D 5-[6-[3-(2-Diethylamino-ethoxy)-phenyl]-pyridazin-3-yl]-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic Acid Tert-Butyl Ester To a solution of the product of Example 24C (0.1 g, 0.26 mmol) and N,N-diethylethanolamine (Aldrich, 87 mL, 0.65 mmol) in 10 mL CH2Cl2 at 0 C. was added polymer-supported triphenylphosphine (Aldrich, 3 mmol/gram, 0.65 mmol, 0.22 g). The diisopropyl azodicarboxylate (DIAD, Aldrich, 0.13 mL, 0.65 mmol) was added dropwise via syringe and, following the addition, the ice-bath was removed and the reaction mixture stirred at ambient temperature for 2 h. The mixture was then filtered, concentrated and purified via column chromatography (SiO2, 1% NH4OH:9% CH3OH:90% CH2Cl2) to give 0.12 g of the title compound (0.25 mmol, 96% yield). MS (DCI/NH3) m/z 482 (M+H)+.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 100-37-8.

Reference:
Patent; Basha, Anwer; Bunnelle, William H.; Dart, Michael J.; Gallagher, Megan E.; Ji, Jianguo; Li, Tao; Pace, Jennifer M.; Ryther, Keith B.; Tietje, Karin R.; US2005/65178; (2005); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2002-24-6, name is 2-Aminoethanol hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. 2002-24-6

9-(2′-hydroxyethylamino)-7-methoxy-1-nitroacridine 7-Methoxy-1-nitro-9-phenoxyacridine (0.69 g) is dissolved in phenol (20 g). Ethanolamine hydrochloride (0.2 g) is added and the mixture is heated at 100 C. for 1.5 hour. The reaction mixture is cooled to room temperature, diluted with dry ether (100 ml), slowly poured into dry ether (300 ml) and acidified with ethereal solution of hydrogen chloride. The resulting precipitate is filtered off, washed twice with ether and crystallized from absolute methanol-ether to give 9-(2′-hydroxyethylamino)-7-methoxy-1-nitroacridine monohydrochloride (0.58 g, 83% yield), m.p. 220 C. (decomp.) 1H NMR (d6DMSO): delta3.45 (t, 2 H, H-2′), 3.65 (t, 2 H, H-1′), 3.80 (s, 3 H, OCH3), 7.30 (dd, 1 H, J1=9.3 Hz, J2=2.5 Hz, H-6), 7.35 (d, 1 H, J=2.5 Hz, H-8), 7.40 (d, 1 H, J=9.3 Hz, H-5), 7.7 (m, 2 H, H-3, H-4), 7.87 (m, 1H, H-2).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2002-24-6, 2-Aminoethanol hydrochloride.

Reference:
Patent; Tiwari, Raj; Miller, Daniel G.; Konopa, Jerzy Kazimierz; Wysocka-Skrzela, Barbara; US2002/37831; (2002); A1;,
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5391-88-8, Adding a certain compound to certain chemical reactions, such as: 5391-88-8, 1-(4-Bromophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5391-88-8, blongs to alcohols-buliding-blocks compound.

l-(4-bromo-phenyl)-ethanol was stirred in aq. HCl at room temperature for 20 h. The excess acid was evaporated under vacuum to give the expected product in quantative yield.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5391-88-8, its application will become more common.

Reference:
Patent; GALAPAGOS NV; MENET, Christel, Jeanne, Marie; BLANC, Javier; HODGES, Alastair, James; BURLI, Roland, Werner; BRECCIA, Perla; BLACKABY, Wesley, Peter; VAN ROMPAEY, Luc, Juliaan, Corina; FLETCHER, Stephen, Robert; WO2010/10184; (2010); A1;,
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78573-45-2, Adding a certain compound to certain chemical reactions, such as: 78573-45-2, 3-(3-(Trifluoromethyl)phenyl)propan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 78573-45-2, blongs to alcohols-buliding-blocks compound.

Example 4 Preparation of methanesulfonic acid 3-(3-trifluoromethyl-phenyl)-propyl ester To a stirred solution of 3-(3-trifluoromethyl-phenyl)-propan-1-ol (250 g, 1.224 mol) and triethylamine (148.52 g, 1.47 mol) in dichloromethane (1.25 L), methanesulfonyl chloride (161.32 g, 1.41 mol) was added at 25 C. to 40 C. and reaction mixture was stirred for 2-3 hours at 40 C. Thereafter, reaction mixture was washed with demineralized water (500 ml*3) and dried over anhydrous sodium sulfate. The dichloromethane was distilled off to give 335 g of title compound having purity 91.58% by HPLC.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,78573-45-2, its application will become more common.

Reference:
Patent; IND-SWIFT LABORATORIES LIMITED; US2011/172455; (2011); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 349-75-7, name is (3-(Trifluoromethyl)phenyl)methanol. A new synthetic method of this compound is introduced below., 349-75-7

A solution of (3-Trifluoromethyl-phenyl)-methanol (180 g, 1.0 mol, 1.0 eqiv.) in dichloromethane (1000 mL) was cooled below 10 C. and phosphorus tribromide (360 g, 1.30 mol, 1.3 eqiv.) was added dropwise in 30 minutes. The mixture was stirred overnight and water was added dropwise until no gas was produced. The solution was washed with saturated sodium hydrogen carbonate (2¡Á500 mL) and water (200 mL). The organic layer dried over anhydrous sodium sulfate and concentrated in vacuo to give the title compound as an brown-red liquid (163 g, 67%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,349-75-7, (3-(Trifluoromethyl)phenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Kalypsys, Inc.; US2005/234046; (2005); A1;,
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In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 42142-52-9 as follows., 42142-52-9

To a solution of 25 g N-methyl-3-phenyl-3-hydroxyphenyl propylamine in hexamethylphosphorous triamide and 19 g potassium f-butoxide at 50-600C was charged 50 g of 2-flourotoluene and the mixture was heated to 105-1100C. The reaction was maintained for 19-20 hours. After the completion of the reaction (monitored by TLC) there were charged 250 ml of water followed by 250 ml toluene and the mixture was stirred for 10-15 minutes. The aqueous and organic layers were separated, then the aqueous layer was extracted with (2*75 ml) toluene. The combined organic layer was washed with (3×75 ml) water and then subjected to distillation to obtain a thick residue. The residue was dissolved in 150 ml of acetone followed by adding of 12.5 g oxalic acid and 200 ml of isopropyl ether and the mixture was stirred for 1-1.5 hours at 0-50C, then the obtained solid was separated by filtration and washed with isopropyl ether (100 ml) resulting in the (+/-)-atomoxetine oxalate with yield 62.4% and a purity of 95.4 area-% by HPLC.

The chemical industry reduces the impact on the environment during synthesis 42142-52-9, I believe this compound will play a more active role in future production and life.

Reference:
Patent; DR. REDDY’S LABORATORIES LTD.; DR. REDDY’S LABORATORIES, INC.; WO2006/37055; (2006); A1;,
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3973-18-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3973-18-0, name is Propynol ethoxylate. This compound has unique chemical properties. The synthetic route is as follows.

4-((2-azidoethyl)amino)-N-(4-fluorophenyl)-N’-hydroxy-1,2,5-oxadiazole-3-carboxamidine (III-4, 0.75g, 2.45mmol) into a 50mL eggplant-shaped bottle,Add 3mL of water and 18mL of acetonitrile solution respectively. Under ice bath, add ethoxylated propynol (290 muL, 2.94 mmol) and cuprous iodide (93 mg, 0.49 mmol),Keep warm and stir for 0.5h, then transfer to room temperature and continue stirring for about 8h.TLC monitored the reaction until the reaction was complete (developing agent: dichloromethane: methanol = 15:1 v/v); the solvent was distilled off under reduced pressure, methanol (20 mL) was added and stirred for 30 min, filtered with suction, and the solvent was distilled off under reduced pressure to obtain a light brown solid , Column chromatography purification (eluent: petroleum ether: ethyl acetate = 2:1 ~ 1:4v/v), to obtain 165mg white solid I-8, the yield was 17.3%,

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3973-18-0, Propynol ethoxylate.

Reference:
Patent; China Pharmaceutical University; Zhu Qihua; Zhang Shan; He Guangchao; Shen Hui; Wang Yiwei; Gu Shuhui; Sun Zeren; Xu Yungen; (24 pag.)CN111138425; (2020); A;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4415-82-1, name is Cyclobutylmethanol. This compound has unique chemical properties. The synthetic route is as follows. 4415-82-1

Step 1. 4-Bromo-5-(cyclobutylmethoxy)-2-nitroaniline Sodium hydride (0.82 g, 60% w/w, 20 mmol) was added at 0 C. to a solution of cyclobutyl/methanol (1.8 mL, 20 mmol) in THF (40 mL). The 0 C. bath was removed, and the reaction mixture was stirred for 30 min. The reaction mixture was again cooled to 0 C. with an ice bath, and 4-bromo-5-fluoro-2-nitroaniline (2.5 g, 11 mmol) was added. The ice bath was removed, and the reaction mixture was stirred for 18 h at room temperature. The reaction was quenched with sat. NH4Cl and then diluted with H2O. The aqueous solution was extracted with EtOAc (125 mL), and the organic layer was separated and washed with brine (100 mL). The resulting organic layer was dried over MgSO4, filtered, and concentrated. Recrystallization from CH2Cl2/hexanes upon cooling at 0 C. overnight afforded the title compound as a red-brown solid (2.3 g, 72%). 1H NMR (300 MHz, CDCl3) delta 8.28 (d, J=1.0 Hz, 1H), 6.07 (s, 1H), 3.90 (d, J=6.0 Hz, 2H), 2.88-2.61 (m, 1H), 2.09 2.25-2.00 (m, 2H), 2.01-1.71 (m, 4H). LCMS calculated for C11H14BrN2O3 (M+H)+: m/z=301.0, 303.0. found: 301.1, 303.1.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4415-82-1, Cyclobutylmethanol.

Reference:
Patent; Incyte Corporation; Yue, Eddy W.; Combs, Andrew P.; Buesking, Andrew W.; US2015/148375; (2015); A1;,
Alcohol – Wikipedia,
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617-94-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 617-94-7, name is 2-Phenyl-2-propanol, molecular formula is C9H12O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of NaH (60 % dispersion in mineral oil, 105 mg, 9.61 mmol) in diethylether (9.5 ml)was added alpha,alpha-dimethyl benzenemethanol (3.04 g, 22.3 mmol) at 0 C. After stirring for 40 min atr oom temperature, trichloroacetonitrile (2.0 ml, 20.0 mmol) was added at 0 C. The reaction mixture was stirred for 3 h at room temperature and concentrated in vacuo. Hexane (2.5 ml) and MeOH (0.1ml) were added to the resulting residue. The mixture was filtered through Celite and concentrated invacuo to give S11 (4.85 g, 78%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 617-94-7, 2-Phenyl-2-propanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ota, Eisuke; Mikame, Yu; Hirai, Go; Nishiyama, Shigeru; Sodeoka, Mikiko; Synlett; vol. 27; 7; (2016); p. 1128 – 1132;,
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