Month: November 2020

6338-55-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6338-55-2, name is 2-(2-(2-Aminoethoxy)ethoxy)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of SL_0498 (120 mg, 177 mumol) in MeCN (15 mL) was added 2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol (26 mg, 177 mumol) followed by NEt3 (74 muL, 531 mumol). The resulting yellow solution was left at 22 C. for 16 hours, at which point TLC analysis indicated complete consumption of starting material. Solvent was removed in vacuo, and crude residue was purified by silica gel chromatography (0?10% MeOH/DCM) to provide 106 mg (87% yield) of SL_0503 as a clear oil. 1H NMR (300 MHz, DMSO-d6) delta 7.22-7.12 (m, 3H), 5.79 (m, 2H), 4.55 (t, J=5.5, 1H), 4.47-4.43 (m, 4H), 4.04 (t, J=4.8 Hz, 2H), 3.62 (t, J=6.6 Hz, 2H), 3.55 (t, J=4.8 Hz, 2H), 3.52-3.45 (m, 14H), 3.44-3.36 (m, 10H), 3.16-3.06 (m, 6H), 1.70 (p, J=6.7 Hz, 2H), 1.49 (p, J=6.9 Hz, 2H), 1.42-1.25 (m, 4H). MS (ESI+) calc’d for C29H55ClN3O13+ [M+H]+ 688.34, found 688.3

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6338-55-2, 2-(2-(2-Aminoethoxy)ethoxy)ethanol.

Reference:
Patent; Promega Corporation; Levin, Sergiy; Ohana, Rachel Friedman; Kirkland, Thomas; Wood, Keith V.; (117 pag.)US2016/355523; (2016); A1;,
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870-72-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 870-72-4, name is Hydroxymethanesulfonic Acid Sodium Salt. This compound has unique chemical properties. The synthetic route is as follows.

175 ml of ethanol and 40 ml of water were added to 32.2 g (0.3 mol) of m-toluidine (manufactured by FUJIFILM Wako Pure Chemical Corporation), and the mixture was stirred at room temperature. To this solution, 48.3 g (0.36 mol) of sodium hydroxymethanesulfonate (manufactured by Tokyo Chemical Industry Co., Ltd.) was added, and the mixture was heated to an external temperature of 100 C. and stirred for 5 hours. After completion of the reaction, the reaction mixture was cooled to room temperature, subjected to filtering, and washed with ethanol. The resulting crystals were dried to obtain 48.8 g of M-1 (yield: 72.8%, white crystals).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 870-72-4, Hydroxymethanesulfonic Acid Sodium Salt.

Reference:
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A common compound: 124-68-5, name is 2-Amino-2-methyl-1-propanol,molecular formula is C4H11NO, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below., 124-68-5

2-Amino-2-methyl-propan-1-ol (53 g, 0.59 mol) and di-tert-butyl dicarbonate (65.0 g, 0.297 mol) were combined in H2O (500 mL) and stirred at 25 C for 1 h. The reaction mixture was extracted with CHCl3 (2 x 250 mL). The organics were dried and concentrated to a white amorphous solid which was recrystallized from hot hexanes to afford desired material (30 g, 53%) as a white solid: 13C NMR (CD3OD, 100 MHz) delta 157.76, 80.135, 70.095, 54.992, 29.247, 24.695.

With the rapid development of chemical substances, we look forward to future research findings about 124-68-5.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2003/99286; (2003); A1;,
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39590-81-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.39590-81-3, name is 1,1-Bis(Hydroxymethyl)cyclopropane, molecular formula is C5H10O2, molecular weight is 102.13, as common compound, the synthetic route is as follows.

Molecular sieves (4 A) and DBU(25 ml, 0.17 mmol) were added to a solution of diol 7a(0.086 g, 0.84 mmol) in DCM (5 ml). The resultingmixture was cooled in an ice bath and trichloracetonitrile(0.34 ml, 3.36 mmol) was added. The reaction was stirredwhile cooling in an ice bath for 4 h until completeconsumtion of the starting material (TLC control, eluentEtOAc-hexane, 1:10). The reaction mixture was filteredthrough a short pad of Celite and the filtrate was evaporated. The residue was purified by flash chromatography onsilica gel column (eluent EtOAc – petroleum ether, 1:20) togive product 1a. Yield 0.270 g (82%). Colorless oil.1H NMR spectrum, delta, ppm: 0.76 (4H, s, CH2CH2); 4.27(4H, s, 2CH2OC(=NH)); 8.25 (2H, s, 2NH). 13C NMRspectrum, delta, ppm: 9.2; 19.7; 72.5; 91.6; 163.1. The productis unstable in the HRMS conditions.

Statistics shows that 39590-81-3 is playing an increasingly important role. we look forward to future research findings about 1,1-Bis(Hydroxymethyl)cyclopropane.

Reference:
Article; Skvorcova, Marija; Grigorjeva, Liene; Jirgensons, Aigars; Chemistry of Heterocyclic Compounds; vol. 53; 9; (2017); p. 989 – 996; Khim. Geterotsikl. Soedin.; vol. 53; 9; (2017); p. 989 – 996,8;,
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623-04-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 623-04-1, name is (4-Aminophenyl)methanol, molecular formula is C7H9NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a 250 mL round bottom flask was added (4-amino-phenyl)-methanol (4.13 g, 33.6 mmol), dichloromethane (50 mL) followed by di-tert-butyl dicarbonate (8.5 g, 36.9 mmol). The mixture was allowed to stir for 18 h under a nitrogen atmosphere. By TLC, a small amount of starting amine remained, which reacted during concentration by rotary evaporation. The product was purified by column chromatography (ethyl acetate : hexanes, 1:1) to yield (4- hydroxymethyl-phenyl)-carbamic acid tert-butyl ester (7.36 g, 33.0 mmol, 98 %) as a white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 623-04-1, (4-Aminophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ATHEROGENICS, INC.; WO2006/31806; (2006); A2;,
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623-04-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 623-04-1, name is (4-Aminophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

p-Aminobenzyl alcohol (PAB-OH) (310 mg, 2.59 mmol) was added to a solution of Fmoc-Leu-OH (830 mg, 2.35 mmol) and /V-ethoxycarbonyl-2-ethoxy-1,2- dihydroquinoline (EEDQ) (630 mg, 2.59 mmol) in anhydrous dichloromethane (DCM) (50 ml_) and the reaction solution was stirred at room temperature overnight. The solvent was then evaporated under reduced pressure and the residue was purified by column chromatography eluting with DCM:MeOH 98:2 to afford 1 (1.00 g, 92%) as a colourless powder

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 623-04-1, (4-Aminophenyl)methanol.

Reference:
Patent; UNIVERSITY OF BRADFORD; LOADMAN, Paul; FALCONER, Robert; GILL, Jason; (57 pag.)WO2017/93719; (2017); A1;,
Alcohol – Wikipedia,
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Some common heterocyclic compound, 346-06-5, molecular formula is C8H7F3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.346-06-5

Example 22 (4Z)-1-ethyl-5-imino-4-[(3-methoxy-4-{[2-(trifluoromethyl)benzyl]oxylphenyl)methylidenelimidazolidin-2-one; [Show Image] To a solution (5 mL) of (4Z)-1-ethyl-4-[(4-hydroxy-3-methoxyphenyl)methylidene]-5-iminoimidazolidin-2-one (200 mg) in tetrahydrofuran were added [2-(trifluoromethyl)phenyl]methanol (278 mg), diethyl azodicarboxylate (700 muL) and triphenylphosphine (414 mg), and the mixture was stirred at room temperature for 16 hr. Water (30 mL) was added and the mixture was extracted with ethyl acetate (50 mL). The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by basic silica gel column chromatography (eluent: hexane/ethyl acetate=10 – 60percent) to give the title compound as a pale-yellow powder (yield: 46.3 mg, 14percent), which was recrystallized from ethyl acetate/n-heptane to give the title compound as colorless crystals (yield: 12.6 mg, 4percent). 1H-NMR (DMSO-d6, 300 MHz):delta1.11 (3H, t, J = 7.6 Hz), 3.56 (2H, d, J = 7.6 Hz), 3.84 (3H, d, J = 1.5 Hz), 5.24 (2H, s), 6.55 (1H, s), 6.96-7.11 (3H, m), 7.55-7.64 (1H, m), 7.69-7.86 (3H, m), 8.73 (1H, brs), 10.19 (1H, brs).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 346-06-5.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP2450352; (2012); A1;,
Alcohol – Wikipedia,
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626-18-6 , The common heterocyclic compound, 626-18-6, name is 1,3-Benzenedimethanol, molecular formula is C8H10O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step 1: Synthesis of 3-(hydroxymethyl)benzyl 2-acetoxybenzoate (CD2-L10-OH) A solution of aspirin acid chloride (3.0 g, 16.7 mmol, freshly prepared from aspirin using oxalyl chloride/DMF method) in dichloromethane (15 mL) was added to a stirred solution of 1,3-benzenedimethanol (HO-L10-OH, 2.3 g, 16.6 mmol) and triethylamine (6.96 mL, 49.9 mmol) in dichloromethane (12 mL) at 0 C. The mixture was stirred at RT for 8 h when TLC analysis of the mixture indicated completion of the reaction. The mixture was concentrated and the residue was partitioned between ethyl acetate (100 mL) and water (50 mL). The organic layer was separated, washed with brine (1*50 mL), dried over anhydrous Na2SO4 and concentrated in vacuo to give the crude oily residue which was purified by column chromatography (silica gel, 150.0 g, 200-400 mesh, 30% EtOAc in hexane) to afford the title compound as colorless oil. Yield: 1.9 g (38.2%); 1H NMR (CDCl3, 300 MHz): delta 1.99 (t, J=5.7 Hz, 1H), 2.14 (s, 3H), 4.73 (d, J=5.4 Hz, 2H), 5.33 (s, 2H), 7.10 (d, J=8.1 Hz, 1H), 7.30-7.43 (m, 5H), 7.58 (dt, J=7.8, 1.5 Hz, 1H), 8.08 (dd, J=7.8, 1.5 Hz, 1H); MS m/z: 301.1 [M+H]+, 323.1 [M+Na]+.

According to the analysis of related databases, 626-18-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PIRAMAL LIFE SCIENCES LIMITED; US2011/263526; (2011); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

107-75-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 107-75-5, name is 7-Hydroxy-3,7-dimethyloctanal, molecular formula is C10H20O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

The experimental methods consisted of two steps: the synthesis step, and the characterization. The synthesis step was begun by weighing of raw materials that were hydroxycitronellal and methyl anthranilate. The aurantiol synthesis was carriedout at a temperature of about 90¡À5C with modification of time for 15 min, 30 min, 1 h, 2 h, 3 h,and 4 hours.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 107-75-5, 7-Hydroxy-3,7-dimethyloctanal, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Irawan, Candra; Indryati, Suci; Lestari, Endang Sri; Hidaningrum, Arinzani; Supriyono; Oriental Journal of Chemistry; vol. 34; 1; (2018); p. 394 – 400;,
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349-75-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 349-75-7, name is (3-(Trifluoromethyl)phenyl)methanol. A new synthetic method of this compound is introduced below.

B-1 (40 mg, 0.10 mmol), benzyl alcohol (12 muL, 0.12 mmol) and triphenylphosphine (39 mg, 0.15 mmol) were dissolved in dichloromethane (1 mL), diisopropyl azodicarboxylate (32 muL, 0.15 mmol) was added dropwise, and the mixture was stirred for several hours. The solvent was evaporated, and the obtained residue was purified by high performance liquid chromatography (water-acetonitrile, each containing 0.1% trifluoroacetic acid) to give the title compound (21 mg, 0.042 mmol, 42%).MS (ESI) m/z 491 (M+H)+1H NMR (400 MHz, DMSO) delta 8.50 (t, J=5.9 Hz, 1H), 7.66 (d, J=4.1 Hz, 1H), 7.44 (d, J=7.0 Hz, 2H), 7.41-7.35 (m, 2H), 7.36 (d, J=4.0 Hz, 1H), 7.35-7.29 (m, 1H), 7.19 (d, J=8.5 Hz, 2H), 6.99-6.93 (m, 2H), 5.09 (s, 2H), 4.27 (dd, J=15.0, 6.1 Hz, 1H), 4.19 (dd, J=15.0, 5.7 Hz, 1H), 4.08 (t, J=5.8 Hz, 1H), 3.55-3.47 (m, 1H), 3.23 (dt, J=10.0, 7.0 Hz, 1H), 1.89-1.77 (m, 3H), 1.68-1.55 (m, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 349-75-7, (3-(Trifluoromethyl)phenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AJINOMOTO CO., INC.; KOBAYASHI, Kaori; Suzuki, Tamotsu; Okuzumi, Tatsuya; US2015/284375; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts