Month: November 2020

78573-45-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 78573-45-2, name is 3-(3-(Trifluoromethyl)phenyl)propan-1-ol, molecular formula is C10H11F3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 21; [00089] A lO liter glass stirred reactor was flushed with nitrogen. The nitrogen blanketing continued during the reaction, and was stopped when the work-up was started. 600 g of compound V, 3.6 liter of Toluene and 492 ml of triethyl amine were charged into the reactor at room temperature. The stirrer was turned on, and then the reactor content was cooled to 4.50C. 255.6 ml of Mesyl chloride (MsCl) was charged drop-wise during 50 minutes, while cooling the reactor. The reactor was heated to 250C, and the triethyl amine salt (TEAHCl) was filtered under reduced pressure, and then the filter cake was washed with 1.8 liter of Toluene (3×600 ml). The organic phase was washed with 500 ml of 0.2N HCl, then the phases were separated, and the organic phase was washed with water (3×1.2L) to achieve pH=7. Toluene was evaporated under reduced pressure. After completion of the evaporation, 1.2 liter of fresh Toluene was charged into the reactor, and the solvent was evaporated at similar conditions. 858g of compound VI were obtained.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 78573-45-2, 3-(3-(Trifluoromethyl)phenyl)propan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TEVA PHARMACEUTICAL INDUSTRIES, LTD.; TEVA PHARMACEUTICALS USA, INC.; WO2006/125026; (2006); A2;,
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111-90-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 111-90-0, name is Diethylene Glycol Monoethyl Ether, molecular formula is C6H14O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 9; 2-rrriig.2,y)-2-r{r(3.R.3a1y.6ai;Vhexahvdrofuror2.3-61furan-3-yloxylcarbonvnamino)-l- { [Cl ,3-benzodioxol-5-ylsulfonylYisobutyl)amino1methyl| -3- (4-IY2-methyl- 1 ,3-thiazol- 4-yl)methoxylphenyl|propyDoxy1 -2-oxoethyl r2-f2-ethoxvethoxv)ethoxvl acetate; EPO Example 9, step 1; [2-(2-ethoxyethoxy)ethoxy] acetic acid; A mixture of tert-butyl chloroacetate (6.00 g, 40.0 mmol), 2-(ethoxyethoxy)ethanol (2.68 g, 20.0 mmol), 18-crown-6 (250 mg), and sodium hydroxide (12.0 g, 0.300 mol) in dioxane (60 mL) was stirred at room temperature for 24 hours. The dark mixture was diluted with water (250 mL) and twice extracted with ether (50 mL). The aqueous phase was acidified with 12N hydrochloric acid (35 mL) and extracted with dichloromethane (3 x 75 mL). The dichloromethane layers, after combining and concentrating under vacuum, were dried by dissolving in dichloromethane (50 ml) and concentrating under vacuum (3x) to afford [2-(2-ethoxyethoxy)ethoxy]acetic acid as a colorless oil (2.8 g, 73%). 1H NMR (400 MHz, DMSO-d6) delta 3.99 (s, 2H), 3.60-3.38 (m, 9H), 3.38 (q, 2H), 1.07 (t, 3H). ES-LCMS m/z 193 (M+H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 111-90-0, Diethylene Glycol Monoethyl Ether, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2006/104646; (2006); A1;,
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Adding a certain compound to certain chemical reactions, such as: 100-37-8, 2-(Diethylamino)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 100-37-8, blongs to alcohols-buliding-blocks compound. 100-37-8

Reference example 81 2-(2-Diethylaminoethoxy-9-tetrahydropyranyladenine 2-Diethylaminoethanol (30ml) was gradually dropped to sodium hydride (0.96g, 40mmol) under a nitrogen atmosphere at 0C over a 15 minutes period. Then the mixture was warmed to room temperature and stirred for 20 minute. 2-Chloro-9-tetrahydropyranyladenine (1.0g, 3.9mmol) which was prepared in Reference example 80 was added thereto and the mixture was stirred at 100C for 1.5 hours.

With the rapid development of chemical substances, we look forward to future research findings about 100-37-8.

Reference:
Patent; Dainippon Sumitomo Pharma Co., Ltd.; AstraZeneca AB; EP1728792; (2006); A1;,
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110-73-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 110-73-6, name is 2-(Ethylamino)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: The mixture of 1.0 mmol of amino alcohol [ethanolamine (0.06 mL), N-methylethanolamine (0.08 mL), or N-ethylethanolamine (0.10 mL)], 1.0 mmol of paraformaldehyde (0.03 g), and 1.0 mmol of >P(O)H reagent [diethyl phosphite (0.13 mL), dibutyl phosphite (0.20 mL), or ethylphenyl-H-phosphinate (0.17 g)] was irradiated in a sealed tube at 80 C for 20 min in a CEM Discover Microwave reactor equipped with a pressure controller. The crude product was purified by flash column chromatography using silica gel and dichloromethane-methanol 9:1 as the eluent.Thus, the following products were prepared:

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 110-73-6, 2-(Ethylamino)ethanol.

Reference:
Article; Tajti, Adam; Szatmari, Enik; Perdih, Franc; Keglevich, Gyoergy; Balint, Erika; Molecules; vol. 24; 8; (2019);,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 106-28-5, name is (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-ol. This compound has unique chemical properties. The synthetic route is as follows. 106-28-5

To the solution of E,E-farnesol (5.0 g, 22 mmol) in anhydrous pyridine (20 mL), acetyl anhydride was added (10 mL) at 0C under argon atmosphere. The reaction mixture was stirred at RT for 12 h. After completion of the reaction, the solution was poured into mixture of water and ice (40 mL) and the product was extracted with ethyl acetate (3×20 mL). Combined organic extracts were washed with saturated aqueous solution of NaHC03, brine and water. Organic layer was dried over anhydrous Na2S04, filtered and evaporated to dryness. EE-Farnesyl acetate was purified by column chromatography using ethyl acetate/hexane (2:98) as eluent to obtain pale yellow oil (5.62 g, 21 mmol, 95%).Analytical results were in compliance with the literature data [Biorg. Med. Chem. 2008, 16, 3108]:Rf= 0.70 (hexane/ethyl acetate, 7:2); NMR (CDCb), delta (ppm): 5.33-5.36 (m, 1H), 5.08-5.11 (m, 2H),,4.59 (d, J = 7.0 Hz, 2H), 1.96-2.13 (m, 8H), 1.71 (s, 3H), 1.68 (s, 3H), 1.60 (s, 3H);13C NMR (CDC13), delta (ppm): 171.0, 142.2, 135.4, 131.2, 124.3, 123.6, 118.3, 61.3, 39.6, 39.5, 26.7, 26.1, 25.6, 21.0, 17.6, 16.4, 15.9.

Statistics shows that 106-28-5 is playing an increasingly important role. we look forward to future research findings about (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-ol.

Reference:
Patent; INSTYTUT FARMACEUTYCZNY; VitaSynth Sp. z.o.o.; KRAJEWSKI, Krzysztof; KUTNER, Andrzej; DZIKOWSKA, Jadwiga; GUTOWSKA, Jadwiga; NAPIORKOWSKI, Marek; WINIARSKI, Jerzy; KUBISZEWSKI, Marek; JEDYNAK, ?ukasz; MORZYCKI, Jacek; WITKOWSKI, Stanis?aw; BAJ, Aneta; WA?EJKO, Piotr; WO2014/58330; (2014); A2;,
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Adding some certain compound to certain chemical reactions, such as: 6338-55-2, name is 2-(2-(2-Aminoethoxy)ethoxy)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6338-55-2. 6338-55-2

A mixed solution of 23.5 g of the compound BP103a03 (1.0 eq), 68.6 g of (Boc) 2O (2.0 eq) and 500 ml of methanol: triethylamine (9: 1) was added to a 1 L three-necked flask, After the completion of the reaction, methanol triethylamine was distilled off, water was added to dissolve, and the mixture was extracted three times with dichloromethane. The organic layer was combined and washed once with water , Dried over anhydrous sodium sulfate, the solvent was distilled off,34.8 g of solid BP103a04 was obtained.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 6338-55-2.

Reference:
Patent; Beu Light Je Ne Bio-me D Keol Tekeunolroji Ko ., L Tidi .; W An-ji-yen-dung; Hwang -yang-ching; Sung -wn-sung; W An-pang; (164 pag.)KR2019/7483; (2019); A;,
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Adding a certain compound to certain chemical reactions, such as: 623-50-7, Ethyl 2-hydroxyacetate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 623-50-7, blongs to alcohols-buliding-blocks compound. 623-50-7

To a stirred mixture of the pyridine 51a (2.00 g, 1.0 eq), the alcohol 51b (1.43 mL, 1.05 eq), CuI (0.05 g, 0.02 eq) is added Cs2CO3 (10.3 g, 2.2 eq) and heated at 70 C. during4 h. The reaction mixture is cooled down to RT, poured into H2O (300 mL) and allowed to stand for 1 h until precipitation. The suspension is filtered, triturated with Et2O/Hex (1:1), dried with toluene azeotrope to give 51c (2.0 g, 70%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,623-50-7, its application will become more common.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2010/261714; (2010); A1;,
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764-48-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 764-48-7, name is Ethylene Glycol Vinyl Ether. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 4-bromo-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione (1.5 g, 4.45 mmol, Intermediate FT) and 2-vinyloxyethanol (784 mg, 8.90 mmol, CAS764-48-7) in dioxane (100 mL) was added P(t-Bu)3 (1.80 g, 889 umol, 2.09 mL, 10% purity), DIPEA (690 mg, 5.34 mmol, 930 uL) and Pd2(dba)3 (407 mg, 444 umol). The reaction mixture was stirred at rt for 12 hours under N2. On completion, the reaction mixture was poured into sat.NH4Cl (30 mL) and extracted with EA (3¡Á100 mL). The combined organic layers were washed with brine (50 mL), dried with anhydrous Na2SO4, filtered and concentrated in vacuo. The residue was purified by column chromatography (SiO2, Petroleum ether/Ethyl acetate=2:1 to 0:1) to give the title compound (600 mg, 33% yield) as a light yellow solid. LC-MS (ESI+) m/z 345.1 (M+H)+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 764-48-7, Ethylene Glycol Vinyl Ether.

Reference:
Patent; Kymera Therapeutics, Inc.; Mainolfi, Nello; Ji, Nan; Kluge, Arthur F.; Weiss, Matthew M.; Zhang, Yi; (1443 pag.)US2019/192668; (2019); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 39590-81-3, name is 1,1-Bis(Hydroxymethyl)cyclopropane, molecular formula is C5H10O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 39590-81-3

Example 136A {1-[(benzyloxy)methyl]cyclopropyl}methanol To a cold (0 C.) solution of 1,1-bis(hydroxymethyl)cyclopropane (5.00 g, 49.0 mmol) in N,N-dimethylformamide (100 ml) was added 60% sodium hydride in mineral oil (1.958 g, 49.0 mmol) in portionwise manner Benzylbromide (5.82 mL, 49.0 mmol) was added to the reaction mixture at room temperature resulting in a slight exotherm. The reaction mixture was stirred at room temperature for 18 hours, and partitioned between 1N HCl solution and methyl tert-butyl ether. The layers were separated and the aqueous layer was washed with CHCl3:isopropyl alcohol (120 mL:40 mL). The combined organic extracts were dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo. The resulting crude product was purified by flash chromatography using a 220 gm cartridge, eluting with 10-70% methyl tert-butyl ether/heptanes to afford 6.58 g of the title product as colorless oil. (70% Yield)1H NMR (400 MHz, CDCl3) delta 0.45-0.51 (m, 2H), 0.51-0.57 (m, 2H), 2.46 (d, J=4.6 Hz, 1H), 3.46 (s, 2H), 3.56 (d, J=3.3 Hz, 2H), 4.54 (s, 2H), 7.27-7.39 (m, 5H). MS (ESI+): M+H=192.8.

The chemical industry reduces the impact on the environment during synthesis 39590-81-3, I believe this compound will play a more active role in future production and life.

Reference:
Patent; AbbVie S.a.r.l.; Galapagos NV; Altenbach, Robert J.; Bogdan, Andrew; Cowart, Marlon D.; Esmieu, William Ramesh; Gfesser, Gregory A.; Greszler, Stephen N.; Koenig, John R.; Kym, Philip R.; Liu, Bo; Malagu, Karine Fabienne; Patel, Sachin V.; Scanio, Marc J.; Searle, Xenia B.; Voight, Eric; Wang, Xeuqing; Yeung, Ming C.; (202 pag.)US2017/15675; (2017); A1;,
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110-73-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 110-73-6, name is 2-(Ethylamino)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 474-[ethyl(2-hydroxyethyl)amino]-/V-methyl-3-(1 /-/-purin-6-ylamino)benzenesulfonamidea) 4-[ethyl(2-hydroxyethyl)amino]-/V-methyl-3-nitrobenzenesulfonamideA solution of 4-fluoro-/V-methyl-3-nitrobenzenesulfonamide (500 mg, 2.14 mmol) in (2-ethylamino)ethanol (951 mg, 10.67 mmol) in a microwave reaction tube was sealed and heated at 1 10 C for 18 h. The mixture was concentrated and purified by flash column chromatography (0-3% MeOH/CHCI3 containing 0.1 % NuEta3¡¤Eta20) to afford the title compound (620 mg, 96%) as a yellow oil. LCMS (ES) m/z 304 (M+H)+; 1H NMR (400 MHz, DMSO-de) delta ppm 1 .10 (t, J=7.07 Hz, 3 H) 2.42 (d, J=4.55 Hz, 3 H) 2.50 (br. s, 2 H) 3.23 – 3.30 (m, 2 H) 3.54 (d, J=5.56 Hz, 2 H) 4.73 (s, 1 H) 7.44 (d, J=9.09 Hz, 2 H) 7.73 (s, 1 H) 8.03 (d, J=2.27 Hz, 1 H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 110-73-6, 2-(Ethylamino)ethanol.

Reference:
Patent; GLAXOSMITHKLINE LLC; HAMMOND, Marlys; KALLANDER, Lara, S.; LAWHORN, Brian, Griffin; PHILP, Joanne; SARPONG, Martha, A.; SEEFELD, Mark, Andrew; WO2011/149827; (2011); A1;,
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