Adding some certain compound to certain chemical reactions, such as: 349-75-7, name is (3-(Trifluoromethyl)phenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 349-75-7. 349-75-7
General procedure: Catalyst preparation: Iron(III) nitrate (112.5 mg, mmol) is added to acetone (2 mL)and the mixture is stirred vigorously in the presence of air for 5 min until complete dissolution of the complex. Bentonite (150 mg) is then added and the resulting suspension stirred for another 5 min. Thus, the solvent is eliminated under reduced pressure on a water bath at 50C (rotary evaporator). After 15 min, the catalyst isobtained as a brown powder. Warning: it is important not to evaporate solvent at higher temperatures (>50 C) orfor longer periods of time (>1 h), which leads to an unstable reagent, which will decompose exothermally in 1-2 h with evolution of nitrogen dioxide. Therefore, wealways prepared the amount of catalyst just necessary for our experiment and immediately engaged it in the oxidation reaction. This takes only 30 min to prepare the catalyst and avoids problem of deactivation. Sequential reaction: 1.5 mL of CH2Cl2 and benzylic alcohol (0.5 mmol) were added tothe just prepared catalyst and stirred until completion (around 4h) at 35C. Then,heating was stopped and the homoallylic alcohol (0.5 mmol) and trimethylsilylchloride (80 L, 0.6 mmol) were added and the reaction mixture was stirred for two hours at room temperature. The crude mixture was then directly chromatographied to give the desired THP with good yield over the two steps RMN 1H (300 MHz, CDCl3) 7.73 – 7.40 (m, 4H), 4.40 (dd, J = 11, 2 Hz, 1H), 4.22 (ddd, J = 12, 5, 2 Hz, 1H),4.17 (tt, J = 12, 5 Hz, 1H), 3.62 (td, J = 12, 2 Hz, 1H), 2.41 (m, 1H), 2.18 (m, 1H), 1.99 (qd, J = 12, 6 Hz, 1H),1.86 (q, J = 12 Hz, 1H). 13C NMR (75 MHz, CDCl3) 142.40 , 130.97 (q, J = 32 Hz), 129.22 – 129.16 (m),129.06 , 124.74 (q, J = 4 Hz), 122.74 (q, J = 4 Hz), 122.40 , 78.63 , 67.48 , 55.41 , 44.69 , 36.81 .RMN 19F (282MHz, CDCl3) -62.59. HRMS (CI): calculated for C12H13ClF3O [M+H]+: 265.0602 found 265.0601
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 349-75-7.
Reference:
Article; Fache, Fabienne; Muselli, Mickael; Piva, Olivier; Synlett; vol. 24; 14; (2013); p. 1781 – 1784;,
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