Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 111-90-0, name is Diethylene Glycol Monoethyl Ether. A new synthetic method of this compound is introduced below., 111-90-0
Diethylene glycol monoethyl ether (1 equiv.) and water (1 mL) were mixed together and stirred on ice before addition of NaOH (2.95 equiv.) and 0.4 M tetrabutylammonium hydroxide (aq) (0.05 equiv.). Once the mixture returned to 0C, epichlorohydrin (2.95 equiv.) was added portion-wise over 3 mm. The mixture was stirred at room temperature for 16 hours. H20 (15 mL) was added and the mixture was extracted with EtOAc (4x 30 mL). The combined extracts were washed with brine (30 mL) and dried over Na2SO4. The extracts were concentrated under reduced pressure. The residue was distilled under vacuum, providing a as a colorless liquid boiling at 110-117C (0.1 mmHg).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,111-90-0, Diethylene Glycol Monoethyl Ether, and friends who are interested can also refer to it.
Reference:
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; UNIVERSITE DE BORDEAUX; INSTITUT POLYTECHNIQUE DE BORDEAUX; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; LECOMMANDOUX, Sebastien, Jean, Marie; GARANGER, Elisabeth, Beatrice, Michele; DEMING, Timothy; (40 pag.)WO2017/21334; (2017); A1;,
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