With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, molecular formula is C8H5F13O, molecular weight is 364.1, as common compound, the synthetic route is as follows.647-42-7
[0087] 2-(Perfluorohexyl)ethanol (18.2 g, 50 mmol) was added to toluene, and potassium hydroxide (3.5 g)/water (3.5 ml) was added to the mixture. Under ice-cooled condition, acrylic acid tert-butyl ester (10.3 ml, 70 mmol) and tetrabutylammonium bromide (1.61 g, 5 mmol) were added, and the mixture was stirred at room temperature for 3 hours. The reaction was quenched by addition of dilute hydrochloric acid. The mixture was separated in an ethyl acetate/water system, and the resulting liquid was concentrated with a rotary evaporator. After column purification, purified ester (7b; 19.0 g, yield 77%) was obtained.
Statistics shows that 647-42-7 is playing an increasingly important role. we look forward to future research findings about 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol.
Reference:
Patent; FUJIFILM Corporation; MIZUMURA Masatoshi; KATOH Shunya; UEMURA Minoru; ISHIWATAYasuhiro; YOSHIKAWA Masaru; MATSUYAMA Hiroshi; EP2738155; (2014); A1;,
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