A common compound: 39590-81-3, name is 1,1-Bis(Hydroxymethyl)cyclopropane,molecular formula is C5H10O2, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below., 39590-81-3
To (5 volumes) of dichloro methane was charged a solution of imidazole and triphenylphosphine. The resultant reaction mixture was cooled to about 0C. Then added a solution of iodine in dichloro methane (5 volumes) at about 0C for about 60 mm.. Thenadded a solution of cyclopropane- 1,1 -diyldimethanol in dichloro methane (5 volumes) at about 0C for about 30 mm. and stirred at 10-15C for about 3 hrs. Then the reaction mass was diluted with brine solution at 10-15C. The organic and aqueous layers were separated and to the organic layer n-heptane (10 volumes) was charged. The total organic layer was washed with saturated sodium sulphite solution (2 times). 70 % of the organic layer wasdistilled at below 45C under vacuum. Then (10 volumes) of n-heptane was added and 12 volumes of the solvent was distilled at below 45C under vacuum. The slurry was filtered on silica bed and washed with n-heptane, the filterate mls were distilled below 45C under vacuum to yield the title compound. Yield: 46%
With the rapid development of chemical substances, we look forward to future research findings about 39590-81-3.
Reference:
Patent; GRANULES INDIA LIMITED; VETUKURI, Prasada Raju Vnkv; GILLA, Goverdhan; RAPOLU, Rajesh Kumar; CHIGURUPATI, Krishna Prasad; (54 pag.)WO2016/103232; (2016); A1;,
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