Adding a certain compound to certain chemical reactions, such as: 346-06-5, (2-(Trifluoromethyl)phenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 346-06-5, blongs to alcohols-buliding-blocks compound. 346-06-5
Example 20 3-Propyl-7-(2-(trifluoromethyl)benzyl)-[1,2,4]triazolo[4,3-a]pyrazin-8(7H)-one: To a solution of 8-chloro-3-propyl-[1 ,2,4]triazolo[4,3-a]pyrazine (88 mg, 0.45 mmol) and (2-(thfluoromethyl)phenyl)methanol (1 1 1 mg, 0.629 mmol) in dimethoxyethane (3.5 ml) was added NaH 60percent in mineral oil (35 mg, 0.88 mmol) at RT and the reaction was stirred for 2 hours. Sodium iodide (1 10 mg, 0.734 mmol) was added and the reaction was heated at 200 ¡ãC for 20 min under microwave irradiation. The reaction mixture was concentrated in vacuo and purified by flash chromatography using a gradient of (petroleum ether: EtOAc: 5percentEt3N/10percentMeOH/85percentEtOAc = 1 :0:0 to 0:1 :0 to 0:0:1 ) to yield 31 mg (17percent) 3-propyl-7-(2-(trifluoromethyl)benzyl)- [1 ,2,4]triazolo[4,3-a]pyrazin-8(7H)-one. 1H NMR (CDCI3 500 MHz): delta 7.76 (m, 1 H), 7.56 (m, 1 H), 7.45 (m ,1 H), 7.40 (m, 1 H), 6.93 (d, J=6.0 Hz, 1 H), 6.60 (d, J=6.0 Hz, 1 H), 5.40 (s, 2 H), 2.98 (t, J=7.6 Hz, 2 H), 1 .92 (m, 2 H), 1 .09 (t, J=7.4 Hz, 3 H). LCMS (MH+): m/z = 337.2, tR (minutes, Method 1 ) = 0.60.
With the rapid development of chemical substances, we look forward to future research findings about 346-06-5.
Reference:
Patent; H. LUNDBECK A/S; KEHLER, Jan; RASMUSSEN, Lars, Kyhn; JESSING, Mikkel; (126 pag.)WO2016/55618; (2016); A1;,
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