647-42-7 ,Some common heterocyclic compound, 647-42-7, molecular formula is C8H5F13O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: A solution of TsCl (8.24212 mmol, 1 equiv) or MsCl (8.24 mmol, 1 equiv) in DCM (24 mL) was added dropwise to a stirred solution of fluorinated alcohol 1-5 (8.24 mmol, 1 equiv) and Et3N (1.78 mL, 1.55 equiv) at 0 C. After complete addition (10 min) the reaction mixture was allowed to reach rt and stirring was continued overnight. Then, the reaction mixture was washed with H2O (34 mL) and brine (34 mL). The organic layer was dried over Na2SO4 and concentrated to dryness under reduced pressure. The resulting crude product was crystallized from MeOH to afford 1a-5b.
According to the analysis of related databases, 647-42-7, the application of this compound in the production field has become more and more popular.
Reference:
Article; Tomaszewska, Joanna; Koroniak-Szejn, Katarzyna; Koroniak, Henryk; Arkivoc; vol. 2017; 2; (2016); p. 421 – 432;,
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