The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2854-16-2, name is 1-Amino-2-methylpropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. 2854-16-2
5-(2 ,4-dichloro-5-(3-fluoropyridin-2-yl)benzamido)- 1 -phenyl- 1 H-pyrazole-3-carboxylicacid (Example 107, 78 g, 166 mmol) was sonicated in DMF (300 mL) with N,Ndiisopropylethylamine (58 mL, 332 mmol) to give a clear solution, which was cooled to 10CC. TPTU (74 g, 249 mmol) was added portionwise and the mixture stirred at 10C for20 minutes. A solution of 1-amino-2-methylpropan-2-ol (22.1 g, 249 mmol) in DMF (50 mL) was added dropwise at 1000 and the mixture then allowed to warm to room temperature and stirred for 16 hours. The reaction mixture was partitioned between EtOAc (600 mL) and water (600 mL). The aqueous layer was separated and extracted with additional EtOAc (3 x 200 mL). The combined organic layers were washed withsaturated aqueous ammonium chloride solution (300 mL), water (5 x 200 mL), dried (magnesium sulphate) and concentrated in vacuo to give an orange oil. The oil was treated with acetonitrile (300 mL) and the resulting solid collected by filtration, washed with acetonitrile and dried under vacuum to afford the title compound as a colourless solid (60 g, 66%).1H NMR (400MHz, DMSO-d6): O ppm 1.09 (s, 6H), 3.21-3.22 (d, 2H), 4.63 (5, 1H), 6.93(5, 1H), 7.45-7.49 (m, 1H), 7.50-7.55 (t, 2H), 7.58-7.65 (m, 3H), 7.69 (5, 1H), 7.80-7.85(t, 1H), 7.87-7.95 (m, 2H), 8.56-8.58 (d, 1H), 10.89 (5, 1H).MS m/z 540.45 [M-Hr
Statistics shows that 2854-16-2 is playing an increasingly important role. we look forward to future research findings about 1-Amino-2-methylpropan-2-ol.
Reference:
Patent; PFIZER INC.; BAGAL, Sharanjeet Kaur; CUI, Jingrong Jean; GREASLEY, Samantha Elizabeth; LUNNEY, Elizabeth Ann; MCALPINE, Indrawan James; NAGATA, Asako; NINKOVIC, Sacha; OMOTO, Kiyoyuki; SKERRATT, Sarah Elizabeth; STORER, Robert Ian; WARMUS, Joseph Scott; WO2015/170218; (2015); A1;,
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