124-68-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 124-68-5, name is 2-Amino-2-methyl-1-propanol, molecular formula is C4H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
2-amino-2-methyl-1-propanol (4.5g,50.56mmol), sodium bicarbonate (8.4g, 100mmol) and sodium carbonate (10.6g, 100mmol) were mixed in a 250mLreaction flask,, a mixture of dioxane and water (160mL, 3:1) was added, the reaction solution was cooled below 0Cunder an ice bath, a solution of di-tert-butyl dicarbonate (13.1g, 59.82mmol) in dioxane (5mL) was added dropwise under stirring. After completion of the addition, the reaction solution was stirred for 6 hours. After completion of the reaction,dioxane was evaporated under reduced pressure, the residue was extracted with ethyl acetate. The organic phase waswashed with saturated brine, dried over anhydrous sodium sulfate and concentrated. The residue was purified by silicagel column chromatography to give 8.2g product with a yield of 85.77%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 124-68-5, 2-Amino-2-methyl-1-propanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Shanghai Pharmaceuticals Holding Co., Ltd.; XIA, Guangxin; LI, Di; ZUO, Hongjian; WU, Guangsheng; DUAN, Lingjun; ZHANG, Jing; MAO, Yu; LIU, Yanjun; (152 pag.)EP3424928; (2019); A1;,
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