Some common heterocyclic compound, 100-37-8, molecular formula is C6H15NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.100-37-8
To a 250 ml four-necked flask equipped with a stirrer and a water separator and a reflux device was added 16.6 g (0.1 mol) of phthalic acid,35.1 g (0.3 mol) of N, N-diethylaminoethanol,0.8 g of titanium sulphate, 20 ml of xylene,Stirring heated to 150 reflux reaction 5h,Until 3.6 g (0.2 mol) of water was separated,The catalyst was removed by filtration (direct reuse)The filtrate was transferred to another 250 ml three-necked flask,The solvent was distilled off under reduced pressure (recovered)Excessed diethylaminoethanol (recycled) and low boiling materials,Add 3.0 g of activated clay to stir for 30 minutes,Cooling to 80 below,Filter yellowColor oil-like liquid phthalic acid bis-diethylaminoethanol ester 35.67g,Yield 90.8%.againThe bis-diethylaminoethacrylate phthalate was mixed with twice as much as citric acid and heated to 120 C,After the citric acid melts,Stirring down the crystallization of salt,To obtain a white powdery solid product, bis-diethylaminoethanol citrate citrate.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 100-37-8.
Reference:
Patent; Suzhou University of Science and Technology; Wang, Yanlin; Wang, Hao; Wang, Yan; Shao, Wei; (13 pag.)CN106008238; (2016); A;,
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