Adding some certain compound to certain chemical reactions, such as: 1074-16-4, name is 2-(2-Bromophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1074-16-4. 1074-16-4
Step 3: 2-(2-bromophenyl)acetaldehydeTo a suspension of PCC (5.9 g, 28 mmol) in DCM (15 mL) was added a solution of 2- (2-bromophenyl)ethanol (3.7 g , 18 mmol) in DCM (20ml_) at room temperature whereupon a slightly exothermic reaction took place with the formation of a black reaction mixture which was kept stirring at room temperature for 15 hours. Then, ethyl ether (150 mL) was added and the mixture was filtered through silica gel on a pad of celite. The residue was washed with ether (50ml_) and the filtrate was concentrated under reduced pressure to afford crude product 2-(2-bromophenyl)acetaldehyde (3.4 g, 17 mmol, 94 % yield) as a light black oil. LCMS (m/z, ES 199 (M+H)
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1074-16-4.
Reference:
Patent; GLAXO GROUP LIMITED; JOHNS, Brian Alvin; SHOTWELL, John Brad; HAIGH, David; WO2012/67663; (2012); A1;,
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