3973-18-0 ,Some common heterocyclic compound, 3973-18-0, molecular formula is C5H8O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
In 175 mL of dichloromethane, 1,2-bis(diphenylphosphino)ethane (1.73 g, 4.40 mmol), cobalt bromide (0.865 g, 4.00 mmol), and zinc iodide (4.2 g, 13.15 mmol) were dissolved, followed by stirring at 30 C. for 30 minutes. Then, 2-(propynyloxy)ethanol (8.94 g, 91.0 mmol) and butadiene (20% by weight toluene solution) (36.8 ml, 136.5 mmol) were added thereto, and then Bu4NBH4 (1.1 g, 4.3 mmol) was added. After stirring at 45 C. for 1 hour, the solvent was evaporated under reduced pressure, and the obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate=5/1). Thus, 11.7 g of the title compound, an alcohol, was obtained as a colorless oily substance. Yield: 85.0%. [0149] 1H NMR (CDCl3, 300 MHz): delta 5.80-5.60 (m, 3H), 3.92 (s, 1H), 3.72 (t, 2H), 3.48 (t, 2H), 2.75-2.60 (m, 4H), 2.22 (brs, 1H)
According to the analysis of related databases, 3973-18-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; TAKASAGO INTERNATIONAL CORPORATION; Touge, Taichiro; Hakamata, Tomohiko; Nara, Hideki; US2014/39220; (2014); A1;,
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