Adding a certain compound to certain chemical reactions, such as: 4254-29-9, 2,3-Dihydro-1H-inden-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 4254-29-9, blongs to alcohols-buliding-blocks compound. 4254-29-9
(41D) Methyl (3S)-3-[4-(2,3-dihydro-1H-inden-2-yloxy)phenyl]-3-ethoxypropionate Methyl (3S)-3-ethoxy-3-(4-hydroxyphenyl)propionate (100 mg, 0.446 mmol) produced in (41C) and indan-2-ol (90 mg, 0.669 mmol) were dissolved in tetrahydrofuran (10 mL), and triphenylphosphine (178 mg, 0.680 mmol) and a 40% diethyl azodicarboxylate toluene solution (309 muL, 0.680 mmol) were added thereto at room temperature, and then, the resulting mixture was stirred under a nitrogen atmosphere at 50 C. for 4 hours. After the reaction solution was cooled to room temperature, the solvent was distilled off under reduced pressure, and the resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate=100:0 to 95:5 (v/v)), whereby the objective title compound was obtained as a yellow oily substance (103 mg, yield: 68%). 1H NMR (CDCl3, 400 MHz): delta1.14 (3H, t, J=7.0 Hz), 2.58 (1H, dd, J=4.7, 15.3 Hz), 2.82 (1H, dd, J=8.9, 15.2 Hz), 3.20 (2H, dd, J=2.7, 16.4 Hz), 3.31-3.41 (4H, m), 3.68 (3H, s), 4.70 (1H, dd, J=5.1, 9.0 Hz), 5.14-5.19 (1H, m), 6.88 (2H, d, J=8.6 Hz), 7.19 (1H, d, J=5.9 Hz), 7.20 (1H, t, J=5.5 Hz), 7.24-7.26 (4H, m)
With the rapid development of chemical substances, we look forward to future research findings about 4254-29-9.
Reference:
Patent; DAIICHI SANKYO COMPANY, LIMITED; US2011/53974; (2011); A1;,
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