111-90-0 , The common heterocyclic compound, 111-90-0, name is Diethylene Glycol Monoethyl Ether, molecular formula is C6H14O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A. 3-(4-(2-(2-ethoxyethoxy)ethoxy)-1,2,5-thiadiazol-3-yl)pyridine To a solution of 2-(2-ethoxyethoxy)ethanol (1.21 g, 9 mmol) and sodium hydride (310 mg, 9 mmol) in dry tetrahydrofuran was added a solution of 3-(4-chloro-1,2,5-thiadiazol-3-yl)pyridine (590 mg, 3 mmol) in dry tetrahydrofuran. The reaction mixture was stirred at room temperature for 2 h. water was added and the mixture was extracted with ether. The ether phase was dried and evaporated to give the title compound.
The synthetic route of 111-90-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVO NORDISK A/S; EP384288; (1995); B1;,
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