928-92-7, Adding a certain compound to certain chemical reactions, such as: 928-92-7, 4-Hexen-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 928-92-7, blongs to alcohols-buliding-blocks compound.
202] To a vial charged with a stir bar were added tram- 9 -¡¤ u n d e e e no i e acid (51.4 g,0,280 mmol), DMAP (6.8 mg, 0.0560 mmol), EDC hydrochloride (106.9 mg, 0.560 mmol), and 2.2 mL dry dich.oromethane under argon atmosphere. 7ram’-4~hexen-l-ol (65.6 pL, 0.560 mmol) was added, and the reaction was stirred for 3 h. The reaction mixture was quenched with a solution of 1M aq. HC1 (5 mL) after which, the product was extracted with DCM (4 x 5 mL). This organic phase was dried over MgS04, filtered, and concentrated in vacuo. The product was purified by column chromatography (5:95 Et20: pentane) to yield the product as a colorless oil (68.3 g, 92% yield).*H NMR (400 MHz, Chlorofomw/i) d 5.46 – 5.25 (m, 4H), 3.99 (t, 6.7 Hz, 2H), 2.27 – 2.15(m, 2H), 1.97 (tdd, J= 7.6, 5.9, 1.5 Hz, 2H), 1.92 – 1.85 (m, 2H), 1.65 – 1.49 (m, 10H), 1.32 – 1.13 (m, 8H).C NMR (101 MHz, CDCb) 6 174.12, 131.69, 130.10, 125.93, 124.76, 63.90, 34.53, 32.70, 29.66, 29.27, 29.26, 29.11, 29.02, 28.60, 25.15, 18.08, 18.06.HRMS (Hi -): [M]+ 7H30O2 Calculated – 266.2237, Found – 266.2246.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,928-92-7, its application will become more common.
Reference:
Patent; CALIFORNIA INSTITUTE OF TECHNOLOGY; AHMED, Tonia, S.; MONTGOMERY, Patrick, T.; GRUBBS, Robert, H.; (104 pag.)WO2019/113019; (2019); A2;,
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